176041-73-9

Basic information

• Product Name: Cyclopropane, 1,1-dichloro-2-isocyanato- (9CI)
• Synonyms: Cyclopropane, 1,1-dichloro-2-isocyanato- (9CI)
• CAS NO: 176041-73-9
• Molecular Formula: C4H3Cl2NO
• Molecular Weight: 151.97872
• Product Categories: HALIDE
• Mol File: 176041-73-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Cyclopropane, 1,1-dichloro-2-isocyanato- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopropane, 1,1-dichloro-2-isocyanato- (9CI)(176041-73-9)
• EPA Substance Registry System: Cyclopropane, 1,1-dichloro-2-isocyanato- (9CI)(176041-73-9)

Safety Data

• Hazardous Substances Data: 176041-73-9(Hazardous Substances Data)

Upstream product

• 186409-72-3 N-(2,2-dichlorocyclopropyl)urea 
• 5365-15-1 2,2-dichloro-1-cyclopropanecarboxylic acid chloride 

Relevant articles and documents

1,3-dipolar cycloaddition of in situ generated 2,2-dimethyl- and 2,2-dichlorodiazocyclopropanes to 3,3-dimethylcyclopropene

2,2-Dimethyl- and 2,2-dichlorocyclopropyl-N-nitrosoureas were synthesized for the first time. Under the action of MeONa/MeOH at -10°C, these compounds generate the corresponding 2,2-dimethyl- and 2,2-dichlorodiazocyclopropanes, which are readily trapped by 3,3-dimethylcyclopropene to give the products of 1,3-dipolar cycloaddition, viz., isomeric substituted spiro{2,3-diazabicyclo[3.1.0]hex-2-ene-4,1′-cyclopropanes}, in yields of about 70%.

Mechanism-based inactivation of α-chymotrypsin

The peptidyl ester derivatives of 2,2-dichlorocyclopropanol and the amide derivative of 2,2-dichlorocyclopropylamine were prepared as novel mechanism-based inactivators of α-chymotrypsin. The esters inactivated α-chymotrypsin irreversibly but the amide did not show any irreversible inhibitory activity toward α-chymotrypsin.