5365-15-1

Usage

General Description

2,2-Dichlorocyclopropanecarbonyl chloride is a highly reactive chemical compound that is used in the production of various pharmaceuticals and agrochemicals. It is also utilized as a building block in organic synthesis to create complex molecules. This colorless liquid has a pungent odor and is highly toxic, flammable, and corrosive. It must be handled with extreme caution and stored in a well-ventilated area away from heat and ignition sources. In the presence of moisture, it can release toxic gases and cause severe skin and eye irritation. Therefore, proper safety measures and protective equipment are necessary when working with this chemical.

Upstream product

• 5365-14-0 2,2-dichlorocyclopropanecarboxylic acid 

Downstream Products

• 61971-73-1 2,2-dichlorocyclopropyl methyl ketone 
• 95650-81-0 1-(4-methoxybenzoyl)-2,2-dichlorocyclopropane 
• 75885-60-8 2,2-dichlorocyclopropanecarboxamide 
• 82789-63-7 1-(2,4,6-trimethylbenzoyl)-2,2-dichlorocyclopropane 
• 56058-22-1 1-Benzoyl-2,2-dichlorocyclopropane 
• 61-33-6 penicillin G 
• 176041-73-9 2,2-dichlorocyclopropyl isocyanate 
• 36159-76-9 4-phenyl-1-naphthol 

Relevant academic research and scientific papers

Mechanism-based inactivation of α-chymotrypsin

The peptidyl ester derivatives of 2,2-dichlorocyclopropanol and the amide derivative of 2,2-dichlorocyclopropylamine were prepared as novel mechanism-based inactivators of α-chymotrypsin. The esters inactivated α-chymotrypsin irreversibly but the amide did not show any irreversible inhibitory activity toward α-chymotrypsin.

REGIOSPECIFICITY IN THE NUCLEOPHILIC RING OPENING REACTIONS OF gem-DICHLOROCYCLOPROPYLCARBINYL CATIONS

gem-Dichlorocyclopropylcarbinyl cations, generated under acidific conditions from the corresponding alcohol or alkene, undergo ring opening by nucleophilic attack exclusively at the halogenated carbon when the alternative electrophilic ring carbon is unsubstituted.In one case, a novel trifluoroacetoxydichloromethyl function has been produced and characterized as a masked carboxylic acid chloride.

CONVENIENT METHOD FOR THE PRODUCTION OF 2,2-DICHLOROCYCLOPROPYL ALKYL AND ARYL KETONES

2,2-Dichlorocyclopropyl alkyl and aryl ketones were obtained with good yields by the reaction of 2,2-dichloro-1-cyclopropanecarbonyl chloride with Grignard reagents or with aromatic hydrocarbons under Friedel-Crafts conditions.

6-(Substituted-cycloalkylcarboxamide) penicillanic acids

Penicillins of the formula SPC1 Or a pharmaceutically-acceptable, nontoxic salt thereof, Wherein R1 and R2 are the same or different and each is hydrogen, fluorine, chlorine or bromine; or when R2 is hydrogen, R1 can also be cyano, hydroxyl, azido, amino or nitro; or R1 and R2 are bonded to a ring carbon atom and constitute a single oxygen atom; R3 is hydrogen, methyl, chlorine, bromine, cyano, methoxy or carboxyl; and n is 2 to 7; Are useful for their antibacterial activity.