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Relevant academic research and scientific papers

Synthesis, structural characterization and biological activity of a trinuclear zinc(II) complex: DNA interaction study and antimicrobial activity

A trinuclear zinc(II) complex [Zn3L2(μ-O2CCH3)2(H2O)2]H2O2CH3OH (1) was synthesized from an in situ reaction between zinc acetate and a Schiff base ligand (H2L = 2-((2-hydroxyphenylimino) methyl)-6-methoxyphenol). The ligand was prepared by (1:1) condensa

Synthesis, characterization, photoluminescence, and computational studies of monoorgano-gallium and -indium complexes containing dianionic tridentate ONE (E = O or S) Schiff bases

The reactions of triorgano-gallium and -indium etherate with dianionic tridentate Schiff bases (2-hydroxy-N-salicylideneaniline (1a), 2-hydroxy-N-(2-hydroxy-3-methoxybenzylidene)aniline (1b), and 2-mercapto-N-salicylideneaniline (1c)) in benzene yielded complexes of the type [RM{O(2-C6H3R′-3)-CH=N(2-C6H 4)E}] (where R = Me, Et; M = Ga, In; R′ = H, OMe; E = O, S) in nearly quantitative yields. These complexes have been characterized by elemental analysis, IR, UV-vis, and NMR (1H and 13C{1H}) spectroscopy. The molecular structures of [MeGa(-O(2-C6H 4)-CH=N(2-C6H4)-O-)] (2a) and [MeGa(-O(2-C 6H3OMe-3)-CH=N(2-C6H4)-O-)] (2b) were established by X-ray crystallography. Photoluminescence data of these complexes showed that the quantum yield was mainly affected by the substituent/groups attached to the phenyl moiety of the ligands rather than the metal atom. Density functional theory calculations have been used to assess all the possible structures and to evaluate the complexation energies corresponding to [MeM{O(2-C6H4)-CH=N(2-C6H4)E}] (M = Ga, In; E = O, S) complexes.

Development and cytotoxicity of Schiff base derivative as a fluorescence probe for the detection of L-Arginine

Inspired from biological counter parts, chemical modification of Schiff base derivatives with function groups may provide a highly efficient method to detect amino acids. Therefore, a fluorescent probe involving Schiff base and hydroxyl group has been des

V(V)-Schiff base species induce adipogenesis through structure-specific influence of genetic targets

Vanadium has been known to exhibit numerous functions in biological systems, projecting exogenous activity linked to regulatory roles in cell metabolism and insulin mimesis. Poised to probe into the vanadium adipogenic potential, reflecting on efficient anti-diabetic drugs, research was launched in our labs to pursue the (a) synthesis of diversely structured Schiff base ligands, as vanadium chelating binders, containing a variably configured o-vanillin core with a specified common organic o-aminophenol tether, (b) synthesis of a family of well-defined soluble vanadium-Schiff base compounds, bearing the above mentioned Schiff ligands (and in one case 4,4'-bipyridine), (c) study of their toxicity profile and adipogenic activity in 3T3-L1 fibroblasts toward mature adipocytes, and (d) determination of molecular biological targets linked to the vanadium-induced cell differentiation process, thereby unravelling factors impacting signaling pathways influencing insulin mimesis. The results suggest that (a) all emerging vanadospecies contain V(V) mononuclear centers bound to Schiff bases (and 4,4'-bipyridine), (b) a welldefined (solid-state and solution) physicochemical profile of all species justifies their selection in biological studies, (c) the vanadium toxicity profile is strongly related to the form of V(V) (complexed forms, substrate-ligand nature), (d) there is a structure-specific behavior of vanadium influencing adipogenesis, and (e) molecular target loci are also influenced by vanadoforms in a structure-specific fashion, thereby collectively projecting an interwoven role of factors emanating from vanadium and impacting cell differentiation and insulin mimetic activity. The so far accrued knowledge constitutes the basis for further development of biomarker-driven structure-specific vanadodrugs, contributing through insulin biomimicry to therapeutic technologies in Diabetes mellitus.

Tetranuclear dysprosium single-molecule magnets: Tunable magnetic interactions and magnetization dynamics through modifying coordination number

The study of mononuclear lanthanide-based systems, where the observed Single Molecule Magnets (SMMs) properties originate from the local magnetic anisotropy of the single lanthanide ion, has been extensively investigated in the literature. The case for po

A trinuclear zinc-Schiff base complex: Biocatalytic activity and cytotoxicity

A novel trinuclear zinc(II) complex [Zn3L2(μ- O2CCH3)2(CH3OH)4] (1) that contains an N,O-donor Schiff base ligand {H2L = 2-[(2-hydroxyphenylimino)methyl]-6-methoxyphen

Hepta-coordinated heteroleptic derivatives of zirconium(IV): Synthesis, structural characterization and ring opening polymerization of ε-caprolactone

A series of new hepta-coordinated heteroleptic derivatives of zirconium(IV) of the types [(CH3COCHCOCH3)2ZrL] (1, 3, 5 and 7) and [(C6H5COCHCOC6H5)2ZrL] (2, 4, 6 and 8) (L?=?a dianionic [ONO]-tridentate ancillary ligand) was synthesized quantitatively by reacting Zr(OPri)4·PriOH with the tridentate Schiff's base ligands H2Lx(H2L1?=?C13H11NO2; H2L2?=?C13H10BrNO2; H2L3?=?C14H13NO3; H2L4?=?C17H13NO2) and β-diketones (acetylacetone/dibenzoylmethane) in a 1:1:2 stoichiometry using dry benzene and ethanol as solvents. All these newly synthesized solid derivatives were fairly soluble in common organic solvents. They were characterized by elemental analyses, FTIR and NMR (1H and13C) spectral studies. Single crystal XRD data of complexes 1, 2, 3 and 5 indicated the hepta-coordination and monomeric nature of these complexes. Furthermore, all these derivatives were tested for the ring opening polymerization of ε-caprolactone. The dibenzoylmethane derivatives were inactive in polymerizing ε-caprolactone unlike the acetylacetonate complexes. The molecular weight and polydispersity index values of polycaprolactone were obtained by GPC analysis. Kinetic studies for the rate of polymerization of ε-caprolactone by these catalytically active zirconium(IV) complexes authenticated the first order dependence of the polymerization rate on the monomer concentration. Among these, complex 3, with an electronegative bromine atom on the Schiff's base moiety, exhibited the best catalytic activity with a conversion of >95% in 2?h.

Fluorescent aluminum chelate complexes as modified precursors for nano-structured alumina

A series of new mononuclear heteroleptic derivatives of aluminum(III), {[(CH3COCHCOCH3)AlL] (1 and 4)}, {[(C6H5COCHCOC6H5)AlL] (2, 5, and 7)}, and {[(C9H6NO)AlL] (3 and 6)}, have been synthesized by reacting Al(OPri)3 with tridentate Schiff base H2Lx (H2L1?=?C13H10BrNO2; H2L2?=?C14H13NO3; H2L3?=?C17H13NO2) and β-diketone/8-hydroxyquinoline (β-diketone?=?acetylacetone/dibenzoylmethane) in 1 : 1 : 1 stoichiometry using anhydrous benzene and ethanol. All the complexes were characterized by elemental analysis, FTIR, and NMR (1H and 13C) spectral studies. Molecular structures obtained from single-crystal XRD of aqua 1 (1a) and DMSO coordinated 2 (2a) authenticate their existence. Further, nanostructured α-alumina was synthesized from 1 by well-established sol–gel method and was characterized by powder XRD, TEM, and EDX analyses.

Transitions of two magnetic interaction states in dinuclear Dy(iii) complexes via subtle structural variations

Herein we explored the transitions of two magnetic interaction states (antiferromagnetic or ferromagnetic) upon structural variations in two dinuclear Dy(iii) complexes.

Fabrication, spectroscopic characterization, calf thymus DNA binding investigation, antioxidant and anticancer activities of some antibiotic azomethine Cu(II), Pd(II), Zn(II) and Cr(III) complexes

This study was conducted to prepare novel azomethine chelates of Cu(II), Pd(II), Zn(II) and Cr(III) with tridentate dianionic azomethine OVAP ligand 2-[(2-hydroxyphenylimino)methyl]-6-methoxyphenol. The prepared compounds were characterized using elementa