17617-05-9

Basic information

• Product Name: 3-Pyridinemethanethiol(6CI,7CI,8CI,9CI)
• Synonyms: 3-Pyridinemethanethiol(6CI,7CI,8CI,9CI);3-(Mercaptomethyl)pyridine;3-Pyridinemethanethiol;(Pyridin-3-yl)methanethiol, 3-(Mercaptomethyl)pyridine;3-(Sulphanylmethyl)pyridine
• CAS NO: 17617-05-9
• Molecular Formula: C₆H₇NS
• Molecular Weight: 125.19
• Product Categories: PYRIDINE
• Mol File: 17617-05-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 231.4°Cat760mmHg
• Flash Point: 93.7°C
• Appearance: /
• Density: 1.107g/cm³
• Vapor Pressure: 0.0948mmHg at 25°C
• Refractive Index: 1.571
• PKA: 8.79±0.10(Predicted)
• CAS DataBase Reference: 3-Pyridinemethanethiol(6CI,7CI,8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinemethanethiol(6CI,7CI,8CI,9CI)(17617-05-9)
• EPA Substance Registry System: 3-Pyridinemethanethiol(6CI,7CI,8CI,9CI)(17617-05-9)

Safety Data

• Hazardous Substances Data: 17617-05-9(Hazardous Substances Data)

Usage

General Description

3-Pyridinemethanethiol is a chemical compound with the molecular formula C6H7NS. It is a light yellow to brown liquid with a strong, unpleasant odor. 3-Pyridinemethanethiol(6CI,7CI,8CI,9CI) is used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also utilized in the production of pigments, dyes, and metal complexes. 3-Pyridinemethanethiol is known for its ability to react with various functional groups, making it a versatile reagent in organic synthesis. Additionally, it has been studied for its potential applications in the treatment of neurodegenerative diseases and as a corrosion inhibitor in industrial processes. However, it is important to handle this compound with caution, as it can be harmful if ingested or comes into contact with the skin.

InChI:InChI=1/C6H7NS/c8-5-6-2-1-3-7-4-6/h1-4,8H,5H2

Upstream product

• 6959-48-4 3-chloromethylpyridinium chloride 
• 82081-34-3 S-(3-picolyl)isothiourea dihydrochloride 
• 4916-55-6 3-(bromomethyl)pyridine hydrobromide 
• 121277-14-3 3-(acetylthiomethyl)pyridine 
• 100-55-0 3-hydroxymethylpyridin 

Downstream Products

• 102207-56-7 3-(butylmercapto-methyl)-pyridine 
• 102206-63-3 3-(ethylmercapto-methyl)-pyridine 
• 102206-50-8 3-(cyclohexylmercapto-methyl)-pyridine 
• 102207-55-6 3-(benzylmercapto-methyl)-pyridine 
• 102206-73-5 3-(propylmercapto-methyl)-pyridine 
• 102206-62-2 3-[(2-dimethylamino-propylmercapto)-methyl]-pyridine 
• 102206-60-0 3-[(2-dimethylamino-ethylmercapto)-methyl]-pyridine 
• 102206-55-3 3-[(2-diethylamino-ethylmercapto)-methyl]-pyridine 
• 69966-44-5 3-methylthiomethylpyridine 
• 288379-38-4 diphenylmethyl 7β-tert-butoxycarbonylamino-3-(3-pyridyl)methylthiomethyl-3-cephem-4-carboxylate 
• 103544-79-2 diphenylmethyl 7β-formamido-3-[(3-pyridyl)methylthio]-3-cephem-4-carboxylate 
• 102206-57-5 3-[(2-diethylamino-propylmercapto)-methyl]-pyridine 
• 99377-96-5 {(3R,4R)-3-((R)-1-Fluoro-ethyl)-2-oxo-4-[2-oxo-3-(pyridin-3-ylmethylsulfanyl)-propyl]-azetidin-1-yl}-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester 
• 3176-70-3 2-(1-mercaptoethyl)benzimidazole 

Relevant articles and documents

PROKINETICIN 1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PAIN

Disclosed are compounds, compositions and methods for treating pain, including inflammatory, visceral, and acute pain. Such compounds are represented by Formula (I) as follows: wherein A1, L1, D, and Q are defined herein.

PROKINETICIN 2 RECEPTOR ANTAGONISTS

The present invention relates to certain novel compounds of Formula (I): and methods for the treatment of prokineticin 2 or prokinetin 2 receptor mediated disorders.

Synthesis and Biological Activity of trans-(+/-)-N-Methyl-2-(3-pirydyl)-2-tetrahydrothiopyrancarbothioamide 1-Oxide (RP 49356) and Analogues: A New Class of Potassium Channel Opener

The synthesis and biological activity of trans-(+/-)-N-methyl-2-(3-pyridyl)-2-tetrahydrothiopyrancarbothioamide 1-oxide (8a, RP 49356) and analoques is reported.These compounds constitute a new structural class of K+-channel opener.The effects of changes in the pyridyl group, thioamide, and thiane ring on in vitro K+-channel opening activity are discussed.A 3-pyridyl or 3-quinolyl group, a small N-alkyl thioamide function, and a thiane oxide ring, in which the sulfoxide is in a trans relationship to thioamide, are preferred for activity.Selected compounds were tested intravenously in the normotensive anaesthetized rat for hypotensive effects, and the activities reflect their in vitro K+-channel opening activity.This led to further evaluation of compound 8a and the selection of the (-)-enantiomer 8b (RP 52891) for development as an antihypertensive and antianginal agent.