88579-39-9Relevant academic research and scientific papers
Site-Selective Switching Strategies to Functionalize Polyazines
Dolewski, Ryan D.,Fricke, Patrick J.,McNally, Andrew
supporting information, p. 8020 - 8026 (2018/06/01)
Many drug fragments and therapeutic compounds contain multiple pyridines and diazines. Developing site-selective reactions where specific C-H bonds can be transformed in polyazine structures would enable rapid access to valuable derivatives. We present a study that addresses this challenge by selectively installing a phosphonium ion as a versatile functional handle. Inherent factors that control site-selectivity are described along with mechanistically driven approaches for site-selective switching, where the C-+PPh3 group can be predictably installed at other positions in the polyazine system. Simple protocols, readily available reagents, and application to complex drug-like molecules make this approach appealing to medicinal chemists.
2-pyrimidine Derivatives: New Bronchosecretolytic Agents
Schickaneder, Helmut,Engler, Heidrun,Szelenyi, Istvan
, p. 547 - 551 (2007/10/02)
2-pyrimidine derivatives (1a-n) promote the excretion of phenol red into the mouse trachea, indicating an increased tracheobronchial secretion.Furthermore, 2-pyrimidine (1a) (tasuldine) produces greater ex
