1762-50-1

Usage

Chemical Properties

Off-White Solid

Uses

Piritramide intermediate.

Upstream product

• 110-89-4 piperidine 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 84254-97-7 1'-benzyl-octahydro-[1,4']bipyridinyl-4'-carbonitrile 

Downstream Products

• 476013-10-2 N-methyl-1-benzyl-4-(piperidin-1-yl)piperidine-4-carboxamide 
• 476013-09-9 N,N-dimethyl-1-benzyl-4-(piperidin-1-yl)piperidine-4-carboxamide 
• 945833-70-5 N,N-diallyl-1'-benzyl-1,4'-bipiperidine-4'-carboxamide 

Relevant academic research and scientific papers

Dual NK2/NK3-antagonists, pharmaceutical compositions comprising them, and processes for their preparation

Dual NK2/NK3-antagonists corresponding to formula I: and physiologically compatible salts of such compounds in which X and R1 to R5 have specific defined meanings, pharmaceutical compositions containing such compounds, methods of using such compounds to treat or inhibit disorders mediated by tachykinin receptors, and a process for preparing such compounds.

4-ARYLMORPHOLIN-3-ONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF

The invention relates to compounds corresponding to formula (I): in which: Ar represents a mono- or disubstituted phenyl; R1 represents an unsubstituted or substituted phenyl; R2 represents: a pyridyl; an unsubstituted or substituted phenyl; a benzyl that is unsubstituted or substituted on the phenyl; R2 may moreover represent: a heterocyclic radical; R3 represents various values. The invention also comprises methods for the compounds preparation, formulations comprising them and therapeutic applications thereof.

NOVEL DUAL NK2/NK3-ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND PROCESSES FOR THEIR PREPARATIONS

The present invention relates to novel dual NK2/NK3-antagonists of formula (I) wherein the meaning of X and R1 to R5 is defined in the claims and in the description and also to pharmaceutical compositions comprising these compounds. Furthermore, the invention relates to processes for the preparation of the novel dual NK2/NK3-antagonists and to their uses.

Novel piperidinecarboxamide derivatives, method for preparing same and pharmaceutical compositions containing same

The invention relates to compounds of formula: as well as their salts with inorganic or organic acids, their solvates and/or their hydrates, which exhibit a very high affinity both for the human NK2 receptors for neurokinin A and for the human NK3 receptors for neurokinin B and are antagonists of the said receptors. The invention also relates to their method of preparation, the pharmaceutical compositions containing them and their use for the preparation of medicaments.