1762-76-1

Upstream product

• 106-53-6 para-bromobenzenethiol 

Downstream Products

• 94520-46-4 O,O-Diaethyl-S-<4-brom-phenylmercapto>-dithiophosphat 
• 91272-11-6 2-p-Bromphenylthiomethyl-2-methyl-2,3-dihydrobenzo-1,4-dioxin 
• 120166-35-0 C₁₅H₁₄BrClS₂ 
• 120166-37-2 C₁₄H₁₁Br₂ClSSe 
• 90584-52-4 N,N-bis<(4-bromophenyl)thio>-1-adamantanamine 
• 124488-40-0 N-{2-[3-(4-Bromo-phenylsulfanyl)-2-chloro-propoxy]-phenyl}-acetamide 
• 128529-39-5 N-<(4-bromophenyl)thio>-2,4,6-triphenylaniline 
• 119118-12-6 N-[2-(4-Bromo-phenylsulfanylmethyl)-2,3-dihydro-benzofuran-5-yl]-acetamide 
• 74880-46-9 (1R,4S,5S,6S)-5-(4-Bromo-phenylsulfanyl)-6-chloro-bicyclo[2.2.1]hept-2-ene 
• 133872-29-4 N¹,N⁵,N⁵-tris<(4-bromophenyl)thio>-2,4-diphenyl-1,3,5-triazapenta-1,3-diene 
• 136490-00-1 N-<(4-bromophenyl)thio>-2,4,6-triphenyl-d₁₅-aniline 
• 124476-19-3 N-{2-[3-(4-Bromo-phenylsulfanyl)-2-chloro-2-methyl-propoxy]-phenyl}-acetamide 
• 119118-20-6 N-[2-(4-Bromo-phenylsulfanylmethyl)-2-methyl-2,3-dihydro-benzofuran-7-yl]-acetamide 
• 74282-62-5 N-(3,5-Di-tert-butylphenyl)-4-bromobenzenesulfenamide 

Relevant academic research and scientific papers

Development of disulfide-derived fructose-1,6-bisphosphatase (FBPase) covalent inhibitors for the treatment of type 2 diabetes

Fructose-1,6-bisphosphatase (FBPase), as a key rate-limiting enzyme in the gluconeogenesis (GNG) pathway, represents a practical therapeutic strategy for type 2 diabetes (T2D). Our previous work first identified cysteine residue 128 (C128) was an important allosteric site in the structure of FBPase, while pharmacologically targeting C128 attenuated the catalytic ability of FBPase. Herein, ten approved cysteine covalent drugs were selected for exploring FBPase inhibitory activities, and the alcohol deterrent disulfiram displayed superior inhibitory efficacy among those drugs. Based on the structure of lead compound disulfiram, 58 disulfide-derived compounds were designed and synthesized for investigating FBPase inhibitory activities. Optimal compound 3a exhibited significant FBPase inhibition and glucose-lowering efficacy in vitro and in vivo. Furthermore, 3a covalently modified the C128 site, and then regulated the N125–S124–S123 allosteric pathway of FBPase in mechanism. In summary, 3a has the potential to be a novel FBPase inhibitor for T2D therapy.

Trichloroisocyanuric acid-promoted thiolation of phosphites by thiols

A simple and convenient method for the synthesis of thiophosphates by coupling of phosphites with thiols under mild conditions has been developed. The reactions were promoted by trichloroisocyanuric acid (TCCA) and were carried out at room temperature in

Unsymmetrical difunctionalization of cyclooctadiene under continuous flow conditions: Expanding the scope of ring opening metathesis polymerization

Functionalized cyclooctenes (FCOEs) are important monomers in ring-opening metathesis polymerization (ROMP). Herein, a new library of disubstituted FCOEs bearing adjacent heteroatoms were synthesized and applied in ROMP. To address the issues associated w

Generation of Oxazolidine-2,4-diones Bearing Sulfur-Substituted Quaternary Carbon Atoms by Oxothiolation/Cyclization of Ynamides

A novel method for metal-free oxothiolation of ynamides to construct oxazolidine-2,4-diones bearing sulfur-substituted quaternary carbon atoms has been developed. It represents a rare C-O bond cleavage of ynamides, as well as a facile and tandem approach for the formation of C-O, C-S, and C-Cl bonds. This redox-neutral protocol can be applied to the synthesis of multisubstituted oxazolidine-2,4-diones with good chemoselectivity and good yields of isolated products under mild conditions.

Formation of α-chalcogenyl acrylamides through unprecedented chalcogen-mediated metal-free oxyfunctionalization of ynamides with DMSO as an oxidant

A novel chalcogen-mediated oxyfunctionalization mode of ynamides for the synthesis of α-chalcogenyl acrylamides has been developed. Independent of metal catalysts, external oxidants and additives, this mild process afforded a range of structurally diverse

A metal free chlorothiolation strategy for synthesis of vinyl sulfides from internal alkynoates

A metal free chlorothiolation approach has been developed for conversion of internal alkynoates to vinyl sulfides and also utilized mild PIDA mediated oxidation to yield the corresponding sulfoxides.

Iron-Induced regio- and stereoselective addition of sulfenyl chlorides to alkynes by a radical pathway

The radical addition of the ClS s-bond in sulfenyl chlorides to various C~C triple bonds has been achieved with excellent regio- and stereoselectivity in the presence of a catalytic amount of a common iron salt. The reaction is compatible with a variety of functional groups and can be scaled up to the gram-scale with no loss in yield. As well as terminal alkynes, internal alkynes underwent stereodefined chlorothiolation to provide tetrasubstituted alkynes. Preliminary mechanistic investigations revealed a plausible radical process involving a sulfur-centered radical intermediate via iron-mediated homolysis of the ClS bond. The resulting chlorothiolation adducts can be readily transformed to the structurally complex alkenyl sulfides by cross-coupling reactions. The present reaction can also be applied to the complementary synthesis of the potentially useful bis-sulfoxide ligands for transition-metal-catalyzed reactions.

Synthesis and biological evaluation of nonsymmetrical aromatic disulfides as novel inhibitors of acetohydroxyacid synthase

46 Novel nonsymmetrical aromatic disulfides containing [1,3,4]thiadiazole or [1,3,4]oxadiazole groups were synthesized and their biological activities were evaluated as inhibitors of acetohydroxyacid synthase (AHAS, EC 2.2.1.6). Besides their strong in vitro inhibition against plant AHAS, compounds 3e and 3f also display 80-100% post-emergence herbicidal activities in greenhouse bioassay at 1500 g/ha dosage. The assay of exogenous branched-chain amino acids supplementation on rape root growth of 3e suggests that the herbicidal activity has relationship with AHAS inhibition.

Catalytic thia-Sommelet-Hauser rearrangement: Application to the synthesis of oxindoles

A series of 3-arylthio-1,3-disubstituted-oxindoles were prepared in good yields by the reaction of α-diazocarbonyl compounds and sulfenamides. The reaction involves a Rh-catalyzed thia-Sommelet-Hauser-type rearrangement.(Figure Presented)

Generation, Isolation, and Characterization of N-(Arylthio)-7-tert-butyl- and N-(Arylthio)-2,7-di-tert-butyl-1-pyrenylaminyl Radicals

N-(Arylthio)-7-tert-butyl-1-pyrenylaminyl (2) and N--2,7-di-tert-butyl-1-pyrenylaminyl radicals (3) are prepared by PbO2 oxidation of N-(arylthio)-7-tert-butyl-1-aminopyrenes and N--2,7-di-tert-butyl-1-aminopyrene, respectively, and studied by ESR and ENDOR spectroscopy.The kinetic ESR study shows that, while aminyls 2 gradually decompose in solution at room temperature, aminyl 3 is quite persistent, even in refluxing benzene, and shows no tendency to dimerize, even at low temperatures.These interesting properties of 3 permit us to isolate 3 as radical crystals in 28-31percent yield.The hyperfine splitting (hfs) constants of 2 and 3, determined by ESR and ENDOR spectroscopic methods, show an extensive delocalization of the unpaired electron onto the pyrene ring.Comparison of the hfs constants of 2 and 3 shows that a more extensive delocalization of the spin into the pyrene ring takes place in 3.This is accounted for in terms of the difference in the conformations of 2 and 3.