17626-74-3

Basic information

• Product Name: Thiazole, 4-(1-Methylethyl)-
• Synonyms: Thiazole, 4-(1-Methylethyl)-;4-Isopropylthiazole;4-(1-Methylethyl)-Thiazole
• CAS NO: 17626-74-3
• Molecular Formula: C₆H₉NS
• Molecular Weight: 127.20736
• Mol File: 17626-74-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 78-80 °C(Press: 16 Torr)
• Appearance: /
• Density: 1.025 g/cm3
• PKA: 3.14±0.10(Predicted)
• CAS DataBase Reference: Thiazole, 4-(1-Methylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiazole, 4-(1-Methylethyl)-(17626-74-3)
• EPA Substance Registry System: Thiazole, 4-(1-Methylethyl)-(17626-74-3)

Safety Data

• Hazardous Substances Data: 17626-74-3(Hazardous Substances Data)

Usage

Description

Thiazole, 4-(1-Methylethyl)-, also known as 4-isopropylthiazole, is a chemical compound belonging to the thiazole family with the molecular formula C7H9NS. It features a five-membered ring structure with nitrogen and sulfur atoms adjacent to each other. Known for its strong, pungent odor, this compound is widely recognized for its savory, meaty flavor profile.

Uses

Used in Food Industry:
Thiazole, 4-(1-Methylethyl)is utilized as a flavoring agent in food products, particularly for enhancing the taste of meat and coffee items. Its unique savory, meaty flavor profile makes it an essential ingredient in creating rich and appetizing food experiences.
Used in Fragrance Production:
Beyond its applications in food, 4-(1-Methylethyl)-thiazole is also employed in the production of fragrances. Its distinct and strong odor makes it a valuable component in creating various scent profiles for perfumes, cosmetics, and other fragranced products.
Used as a Chemical Intermediate:
In the realm of chemical synthesis, Thiazole, 4-(1-Methylethyl)serves as a crucial intermediate. It plays a significant role in the synthesis of other compounds, contributing to the development of new materials and products across different industries.

Upstream product

• 115-08-2 thiocarboxamide 
• 19967-55-6 1-bromo-3-methyl-2-butanone 

Relevant articles and documents

Solid-phase parallel synthesis and SAR of 4-amidofuran-3-one inhibitors of cathepsin S: Effect of sulfonamides P3 substituents on potency and selectivity

Highly potent and selective 4-amidofuran-3-one inhibitors of cathepsin S are described. The synthesis and structure-activity relationship of a series of inhibitors with a sulfonamide moiety in the P3 position is presented. Several members of the series show sub-nanomolar inhibition of the target enzyme as well as an excellent selectivity profile and good cellular potency. Molecular modeling of the most interesting inhibitors describes interactions in the extended S3 pocket and explains the observed selectivity towards cathepsin K.

CATHEPSIN S INHIBITORS

Compounds of the formula (I) where R1 is C1-C4 straight or branched alkyl, optionally substituted with up to three substituents selected from halo and hydroxy; R2 is halo, hydroxy, methyloxy, or C1-C2 alkyl, which alkyl is optionally substituted with up to three halogens or an hydroxy or a methyloxy; D is - C3-C7 alkylene-, thereby defining a cycloalkyl ring; E is -C(=O)-, -S(=O)m-, -NRdS(=O)m-, -NRaC(=O)-, -OC(=O)-, R3 is an optionally substituted carbocyclic or heterocyclic ring R10 is H, ORc, SRc or together with the gem H is =O or (ORc)2; Ra is independently selected from H, C1-C4 alkyl; have utility in the inhibition of cathepsin S and are thus useful pharmaceuticals against disorders such as autoimmune disorders and chronic pain.