17635-24-4

Basic information

• Product Name: Quinoxaline, 6-fluoro-2,3-dimethyl- (8CI)
• Synonyms: Quinoxaline, 6-fluoro-2,3-dimethyl- (8CI);6-FLUORO-2,3-DIMETHYLQUINOXALINE
• CAS NO: 17635-24-4
• Molecular Formula: C10H9FN2
• Molecular Weight: 176.1902632
• Product Categories: PIPERIDINE
• Mol File: 17635-24-4.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Quinoxaline, 6-fluoro-2,3-dimethyl- (8CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Quinoxaline, 6-fluoro-2,3-dimethyl- (8CI)(17635-24-4)
• EPA Substance Registry System: Quinoxaline, 6-fluoro-2,3-dimethyl- (8CI)(17635-24-4)

Safety Data

• Hazardous Substances Data: 17635-24-4(Hazardous Substances Data)

Usage

General Description

Quinoxaline, 6-fluoro-2,3-dimethyl- (8CI) is a chemical compound with the molecular formula C10H8FNO. It is a derivative of quinoxaline, which is a heterocyclic compound containing a benzene ring fused to a pyrazine ring. The presence of a fluorine atom at the 6th position and two methyl groups at the 2nd and 3rd positions makes this compound unique. Quinoxaline derivatives have been studied for their various potential pharmacological activities, including antimicrobial, antiviral, antitumor, and antibacterial properties. The specific properties and potential uses of this particular compound may be further investigated in the fields of pharmaceuticals and medicinal chemistry.

Upstream product

• 364-78-3 2-nitro-4-fluoroaniline 
• 431-03-8 dimethylglyoxal 
• 513-85-9 2.3-butanediol 
• 367-31-7 4-fluoro-1,2-phenylenediamine 

Downstream Products

• 941283-06-3 2,3-dimethyl-6-(1-pyrrolidinyl)quinoxaline 
• 941283-07-4 2,3-dimethyl-6-(1-piperidinyl)quinoxaline 
• 941283-14-3 2,3-dimethyl-6-(1H-imidazol-1-yl)quinoxaline 

Relevant articles and documents

NaOH-Mediated Direct Synthesis of Quinoxalines from o-Nitroanilines and Alcohols via a Hydrogen-Transfer Strategy

A NaOH-mediated sustainable synthesis of functionalized quinoxalines is disclosed via redox condensation of o-nitroamines with diols and α-hydroxy ketones. Under optimized conditions, various o-nitroamines and alcohols are well tolerated to generate the desired products in 44-99% yields without transition metals and external redox additives.

One-pot synthesis of quinoxalines from reductive coupling of 2-nitroanilines and 1,2-diketones using indium

The one-pot reduction-cyclization of 2-nitroanilines and 1,2-diketones to give quinoxalines was investigated. Using indium and an appropriate acid such as acetic acid or indium(III) chloride, various quinoxaline derivatives including 2,3-dialkylquinoxalines, 2,3-diphenylquinoxalines, 2,3-di-2-thiophenylquinoxalines, 2,3-di(pyridin-2-yl)quinoxalines, and dibenzo[a,c]phenazines were synthesized in moderate to excellent yield.

Aqueous hydrofluoric acid catalyzed facile synthesis of 2,3,6-substituted quinoxalines

A versatile synthetic route for the preparation of 2,3,6-trisubstituted quinoxalines in excellent yield is developed from θ-diamines and 1,2-dicarbonyl compounds in which aqueous hydrofluoric acid was employed as the medium and catalyst. Other salient features of this protocol include milder conditions, absence of coupling agents, and easy workup procedures.