17645-51-1

Basic information

• Product Name: VALINE BENZYL ESTER
• Synonyms: VALINE BENZYL ESTER;D,L-Valine Benzyl Ester;Valine Phenylmethyl Ester
• CAS NO: 17645-51-1
• Molecular Formula: C₁₂H₁₇NO₂
• Molecular Weight: 207.26888
• Product Categories: Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives
• Mol File: 17645-51-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: VALINE BENZYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: VALINE BENZYL ESTER(17645-51-1)
• EPA Substance Registry System: VALINE BENZYL ESTER(17645-51-1)

Safety Data

• Hazardous Substances Data: 17645-51-1(Hazardous Substances Data)

Usage

Chemical Properties

Clear Colourless Oil

Upstream product

• 516-06-3 D,L-valine 
• 100-51-6 benzyl alcohol 
• 4070-48-8 L-valine methyl ester 
• 100-44-7 benzyl chloride 
• 1149-26-4 N-benzyloxycarbonylvaline 
• 98-11-3 benzenesulfonic acid 
• 126400-97-3 (+/-)-Benzyl N-(benzyloxycarbonyl)valinate 

Downstream Products

• 1286729-23-4 C₁₉H₂₀ClNO₂ 
• 1286729-26-7 C₁₆H₁₉NO₃ 
• 1286729-41-6 C₁₆H₁₉NO₃ 
• 1245736-11-1 C₁₃H₁₅NO₂ 
• 143998-27-0 benzyl α-isopropyldiazoacetate 
• 2634-21-1 O-(2-Methoxycarbonyl-benzoyl)-DL-(α-hydroxy-isovaleryl)-DL-valin 
• 21760-98-5 L-valine benzyl ester 
• 46460-17-7 (R)-O-benzyl 2-amino-3-methylbutanoate 
• 17080-08-9 -DL-valin-benzylester 
• 17080-18-1 -DL-valin-benzylester 

Relevant articles and documents

A synthetic amino acid N-methylation method and its product and application (by machine translation)

The invention belongs to the technical field of amino acid polypeptide synthesis, discloses a synthetic amino acid N-methylation method and its product and application. This method passes the benzyl protection of a carboxyl group of the amino acid, trifluoroacetyl protection of the amino group, after methylation, get N-methylation of the amino acid. N obtained by the method of this invention-methyl (trifluoro-acetyl)-amino acid benzyl ester, can be directly used for polypeptide synthesis N-methyl structure having the amino acid benzyl ester product, and it has good selective deprotection of, its N the C-end-to-end and selectively deprotected. With foreign Ag 2 O/CH 3 I/Boc method (hypertoxic, high cost) and NaH / (CH 3 O) 2 SO 2 method compared with (hypertoxic), and the like, the method of the invention high yield, the use of the virulent reagent-free, safe and non-toxic, the operation is simple, common reagent to the raw material, the cost is low, and the structure strong pertinence, racemation a low possibility of the product obtained, it has broad industrial prospects. (by machine translation)

Concise synthesis of α-methylene-β-hydroxy-γ-carboxy- γ-lactams

A concise protocol for the synthesis of α-methylene-β-hydroxy- γ-carboxy-γ-lactams has been described via alkylation of amino acid derived iminoesters with α-bromomethylmethacrylate, followed by allylic hydroxylation. All the synthesized compounds have been evaluated for their cytotoxicity on multiple myeloma cancer cell lines.

4-pentenoyl groups for derivatization and protection of amino acids

A method of separating a racemic mixture of amino acid enantiomers, which entails reacting the mixture with a 4-pentenoyl compound, thereby derivatizing the enantiomers to form two diastereomers, and separating the diastereomers.