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17648-03-2

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17648-03-2 Usage

General Description

2,3-Dihydro-9,10-dihydroxy-1,4-anthracenedione, also known as aloe-emodin, is a naturally occurring anthraquinone compound found in the leaves of the Aloe plant. It has been used in traditional medicine for its anti-inflammatory, anti-bacterial, anti-viral, and anti-cancer properties. Aloe-emodin has been studied for its potential as a treatment for various conditions, including diabetes, obesity, and skin disorders. It acts as a potent inhibitor of cancer cell proliferation and has shown promising results in inhibiting the growth of tumor cells in some studies. Additionally, aloe-emodin has demonstrated antioxidant and anti-fibrotic effects, making it a potential therapeutic agent for various diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 17648-03-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,6,4 and 8 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 17648-03:
(7*1)+(6*7)+(5*6)+(4*4)+(3*8)+(2*0)+(1*3)=122
122 % 10 = 2
So 17648-03-2 is a valid CAS Registry Number.
InChI:InChI=1/C14H10O4/c15-9-5-6-10(16)12-11(9)13(17)7-3-1-2-4-8(7)14(12)18/h1-4,17-18H,5-6H2

17648-03-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,3-DIHYDRO-9,10-DIHYDROXY-1,4-ANTHRACENEDIONE

1.2 Other means of identification

Product number -
Other names 9,10-DIHYDROXY-2,3-DIHYDRO-ANTHRACENE-1,4-DIONE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:17648-03-2 SDS

17648-03-2Relevant articles and documents

Synthesis of 1,4-Anthracene-9,10-dione derivatives and their regulation of nitric oxide, IL-1β and TNF-α in activated RAW264.7 cells

Correa, Tais Arthur,Alves, Caio C. S.,Castro, Sandra B. R.,Oliveira, Erick E.,Franco, Lucas S.,Ferreira, Ana P.,De Almeida, Mauro V.

, p. 463 - 467 (2013)

Mitoxantrone is an anthracenedione antineoplastic and immunosuppressive agent approved for multiple sclerosis treatment. Novel mono- and disubstituted anthraquinone derivatives, analogues of mitoxantrone, were synthesized through the addition of lipophilic amino alcohols and evaluated for their effect on IL-1β, TNF-α and nitric oxide production by LPS/IFN-γ-stimulated RAW264.7 cells. The disubstituted 1,4-anthracene-9,10-dione 10 showed significant inhibition of nitric oxide, TNF-α and IL-1β production at the concentration of 5 μg/mL, with a much lower cytotoxicity than mitoxantrone. The monosubstituted 3, 4, 11, 12 and 13 also displayed a moderate to good inhibitory capacity on IL-1β production. However, the methylated compounds 11, 12 and 13 failed to inhibit the TNF-α production, and compound 13 was the only one to decrease the production of nitric oxide. None of these derivatives was toxic at the tested concentrations. Compounds 10 and 13 had better inhibitory capacity of the inflammatory mediators analyzed, with reliable viability of the cells.

A new InCl3-catalyzed reduction of anthrones and anthraquinones by using aluminum powder in aqueous media

Wang, Chunyan,Wan, Jieping,Zheng, Zhiguo,Pan, Yuanjiang

, p. 5071 - 5075 (2008/02/01)

InCl3-catalyzed reduction of anthrones and anthraquinones was investigated under different conditions. A new synthetic method for anthracenes in aqueous media under mild conditions is described.

New 1,4-anthracene-9,10-dione derivatives as potential anticancer agents

Zagotto,Supino,Favini,Moro,Palumbo

, p. 1 - 5 (2007/10/03)

The amino-substituted anthracene-9,10-dione (9,10-anthraquinone) derivatives represent one of the most important classes of potential anticancer agents. To better understand the basic rules governing DNA sequence specificity, we have recently synthesized a new class of d- and l- aminoacyl-anthraquinone derivatives. We have tested these new compounds as cytotoxic agents, and we have correlated their activity with the configuration of the chiral aminoacyl moiety. Molecular modeling studies have been performed to compare the test drugs in terms of steric overlapping. (C) 2000 Elsevier Science S.A.

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