176486-63-8

Basic information

• Product Name: (2S,4R)-FMOC-4-AMINO-1-BOC-PYRROLIDINE-2-CARBOXYLIC ACID
• Synonyms: (4R)-1-Boc-4-(FMoc-aMino)-L-proline;(2S,4R)-4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-1,2-Pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) ester;(2S,4R)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-1-(tert-butoxycarbonyl)pyrrolidine-2-car;Fmoc-(2S,4R)-4-amino-1-Boc-pyrrolidine-2-carboxylic acid≥ 99% (HPLC);RARECHEM EM WB 0068;N-BOC-TRANS-4-N-FMOC-AMINO-L-PROLINE;FMOC(2S,4R)-ABPC;FMOC-(2S,4R)-4-AMINO-1-BOC-PYRROLIDINE-2-CARBOXYLIC ACID
• CAS NO: 176486-63-8
• Molecular Formula: C₂₅H₂₈N₂O₆
• Molecular Weight: 452.5
• Product Categories: FMOC
• Mol File: 176486-63-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 199 °C(lit.)
• Boiling Point: 650.2oC at 760 mmHg
• Flash Point: 347oC
• Appearance: White/off-white/palebrown/Powder
• Density: 1.33
• Vapor Pressure: 8.58E-18mmHg at 25°C
• Refractive Index: 1.627
• Storage Temp.: Store at 0-5°C
• PKA: 3.81±0.40(Predicted)
• CAS DataBase Reference: (2S,4R)-FMOC-4-AMINO-1-BOC-PYRROLIDINE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4R)-FMOC-4-AMINO-1-BOC-PYRROLIDINE-2-CARBOXYLIC ACID(176486-63-8)
• EPA Substance Registry System: (2S,4R)-FMOC-4-AMINO-1-BOC-PYRROLIDINE-2-CARBOXYLIC ACID(176486-63-8)

Safety Data

• Statements: 22
• Safety Statements: 36/37/38
• WGK Germany: 3
• Hazardous Substances Data: 176486-63-8(Hazardous Substances Data)

Usage

Chemical Properties

solid

Uses

N-?Boc-?trans-?4-?N-?Fmoc-?amino-?L-?proline is used to prepare NS3-?serine protease inhibitors of hepatitis C virus.

InChI:InChI=1/C25H28N2O6/c1-25(2,3)33-24(31)27-13-15(12-21(27)22(28)29)26-23(30)32-14-20-18-10-6-4-8-16(18)17-9-5-7-11-19(17)20/h4-11,15,20-21H,12-14H2,1-3H3,(H,26,30)(H,28,29)/t15-,21+/m1/s1

Upstream product

• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 132622-69-6 (2S,4R)-4-amino-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid 
• 185304-19-2 (2S,4R)-2-benzyl 1-tert-butyl 4-azidopyrrolidine-1,2-dicarboxylate 

Downstream Products

• 914653-06-8 N^α-benzyl-trans-4-N-amino-L-prolinamide 
• 914652-93-0 N^α-benzyl-trans-4-N-(9-fluorenylmethoxycarbonyl)-amino-L-prolinamide 
• 914652-97-4 C₂₃H₃₆N₈O₆ 
• 132622-69-6 (2S,4R)-4-amino-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid 
• 862120-41-0 Fmoc-4-amino-2-(1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-pyrrolidine-1-carbocyclic acid tert-butyl ester 
• 943134-39-2 (2S,4R)-1-(2-aminoacetyl)-4-benzoylamino-pyrrolidine-2-carboxylic acid 
• 1029683-82-6 C₈₃H₈₂N₁₈O₁₄ 
• 1029683-86-0 C₉₇H₁₀₂N₂₂O₁₈ 
• 1029683-80-4 C₈₃H₈₂N₁₈O₁₄ 
• 1029683-84-8 C₉₇H₁₀₂N₂₂O₁₈ 
• 1029683-83-7 C₈₂H₈₄N₁₆O₁₄ 
• 1029683-87-1 C₉₆H₁₀₄N₂₀O₁₈ 
• 1029683-81-5 C₈₃H₈₂N₁₆O₁₆ 
• 1029683-85-9 C₉₇H₁₀₂N₂₀O₂₀ 

Relevant articles and documents

INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF

Provided herein are compounds that inhibit pKal, a serine protease whose activity is responsible for proteolytically cleaving kininogen and generating the potent vasodilator and pro-inflammatory peptide bradykinin, which can lead to painful and debilitating inflammatory attacks (e.g., edema). Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating pKal-related diseases and disorders (e.g., edema) with the compounds in a subject, by administering the compounds and/or compositions described herein.

NOVEL PEPTIDES AS NS3-SERINE PROTEASE INHIBITORS OF HEPATITIS C VIRUS

The present invention discloses novel peptide compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such peptides as well as methods of using them to treat disorders associated with the HCV protease.