(2S,4R)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid

Base Information

• Chemical Name: (2S,4R)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid
• CAS No.: 176486-63-8
• Molecular Formula: C25H28 N2 O6
• Molecular Weight: 452.507
• Hs Code.: 29339900
• European Community (EC) Number: 800-773-1
• Nikkaji Number: J1.518.520A
• Mol file: 176486-63-8.mol

Synonyms:176486-63-8;(2S,4R)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid;N-Boc-trans-4-N-Fmoc-amino-L-proline;(2S,4R)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid;(2S,4R)-Fmoc-4-Amino-1-Boc-Pyrrolidine-2-Carboxylic Acid;(2S,4R)-4-(((9H-fluoren-9-yl)methoxy)carbonylamino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid;(2S,4R)-4-[[[(9H-Fluoren-9-yl)methoxy]carbonyl]amino]-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid;MFCD00673783;(2S,4R)-N-(tert-Butoxycarbonyl)-4-N-(9-fluorenylmethoxycarbonyl)aminopyrrolidine-2-carboxylic acid;SCHEMBL1536521;UPXRTVAIJMUAQR-VFNWGFHPSA-N;AKOS015995239;AKOS016007509;AM10121;CS-W008446;HY-W008446;DS-15395;PD196576;N-Boc-trans-4-N-Fmoc-amino-L-proline, 97%;EN300-331976;A881517;J-011198;N-?BOC-?TRANS-?4-?N-?FMOC-?AMINO-?D-?PROLINE;(2S,4R)-4-(((9H-fluoren-9-yl)methoxy)carbonylamino)-1-BOC-pyrrolidine-2-carboxylic acid;(2S,4R)-trans-N-alpha-t-Butyloxycarbonyl-4-(9-fluorenylmethyloxycarbonyl)amino-L-proline;1-(tert-Butoxycarbonyl)-4beta-(9H-fluorene-9-ylmethoxycarbonylamino)-L-proline;(2S,4R)-1-[(tert-butoxy)carbonyl]-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pyrrolidine-2-carboxylic acid;(2S,4R)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylicacid;1,2-Pyrrolidinedicarboxylicacid,4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-,1-(1,1-dimethylethyl)ester,(2S,4R)-

Chemical Property of (2S,4R)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid

Chemical Property:

• Vapor Pressure: 8.58E-18mmHg at 25°C
• Melting Point: 199 °C(lit.)
• Boiling Point: 650.2oC at 760 mmHg
• PKA: 3.81±0.40(Predicted)
• Flash Point: 347oC
• PSA: 105.17000
• Density: 1.33g/cm3
• LogP: 4.31650
• Storage Temp.: Store at 0-5°C
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 7
• Exact Mass: 452.19473662
• Heavy Atom Count: 33
• Complexity: 728

Purity/Quality:

99% ^*data from raw suppliers

N-Boc-trans-4-N-Fmoc-amino-L-proline ^*data from reagent suppliers

Safty Information:

• Statements: 22
• Safety Statements: 36/37/38

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1CC(CC1C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24
• Isomeric SMILES: CC(C)(C)OC(=O)N1C[C@@H](C[C@H]1C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24
• Uses: N-?Boc-?trans-?4-?N-?Fmoc-?amino-?L-?proline is used to prepare NS3-?serine protease inhibitors of hepatitis C virus.

Technology Process of (2S,4R)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid

There total 2 articles about (2S,4R)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) + (2S,4R)-4-amino-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid (132622-69-6) → (2S,4R)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid (176486-63-8)

Guidance literature:

With sodium carbonate; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1021/jm701214z

Reference yield:

fluorenylmethyl succinyl carbonate + (2S,4R)-2-benzyl 1-tert-butyl 4-azidopyrrolidine-1,2-dicarboxylate (185304-19-2) → (2S,4R)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid (176486-63-8)

Guidance literature:

With sodium carbonate; citric acid; palladium; In 1,4-dioxane; methanol; ethanol; water;

Reference yield: 50.0%

bromo(3-fluorophenyl)magnesium (17318-03-5) + (2S,4R)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid (176486-63-8) → (2S,4R)-tert-butyl 4-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-(3-fluoro-benzoyl)pyrrolidine-1-carboxylate (1018910-35-4)

Guidance literature:

(2S,4R)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid; With triethylamine; Diphenylphosphinic chloride; In dichloromethane; at 0 ℃; for 2h;

bromo(3-fluorophenyl)magnesium; In tetrahydrofuran; at -78 - 20 ℃;

upstream raw materials:

(2S,4R)-2-benzyl 1-tert-butyl 4-azidopyrrolidine-1,2-dicarboxylate

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

(2S,4R)-4-amino-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid

Downstream raw materials:

N^α-benzyl-trans-4-N-amino-L-prolinamide

N^α-benzyl-trans-4-N-(9-fluorenylmethoxycarbonyl)-amino-L-prolinamide

C₂₃H₃₆N₈O₆

(2S,4R)-4-amino-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 176486-63-8 (2S,4R)-FMOC-4-AMINO-1-BOC-PYRROLIDINE-2-CARBOXYLIC ACID

Send

Send

Metric Ton KG G Pound L ML

Send

Send