176502-44-6Relevant articles and documents
New cobalt-catalyzed cycloisomerization of ε-acetylenic β-keto esters. Application to a powerful cyclization reactions cascade
Cruciani, Paul,Stammler, Robert,Aubert, Corinne,Malacria, Max
, p. 2699 - 2708 (1996)
The full details of investigations into the cobalt(I)-catalyzed ene type reaction of ε-acetylenic β-keto esters to form highly functionalized methylenecyelopentanes are described. The observed regio-, chemo-, and stereoselectivities support a process of cycloisomerization which controls the relative stereochemistry of two contiguous stereogenic centers. An efficient route to the basic skeleton of the phyllocladane family has been achieved via a one-pot sequence of cyclizations: ene type, [2 + 2 + 2], [4 + 2]. This new cascade created six carbon-carbon bonds and four rings in a totally stereoselective manner from an easily accessible acyclic polyunsaturated precursor.
Studies on Diastereoselectivity of the Cobalt(I) Catalyzed Cycloisomerization of Substituted ε-Acetylenic β-Ketoester.
Cruciani, Paul,Aubert, Corinne,Malacria, Max
, p. 6677 - 6680 (1994)
Cobalt(I) catalyzed cycloisomerization of a ε-acetylenic β'-alkyl β-ketoester led to highly functionalized methylenecyclopentanes with stereocontrol of two contiguous centers.The level of diastereoselectivity is moderate to high (de = 12-92percent).
