176530-46-4

Basic information

• Product Name: 2-(Methylsulfanyl)thieno[3,2-d]pyrimidin-4(1H)one
• Synonyms: 2-(Methylsulfanyl)thieno[3,2-d]pyrimidin-4(1H)one;2-(Methylthio)thieno[3,2-d]pyrimidin-4(3H)-one
• CAS NO: 176530-46-4
• Molecular Formula: C7H6 N2 O S2
• Molecular Weight: 198.27
• Mol File: 176530-46-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(Methylsulfanyl)thieno[3,2-d]pyrimidin-4(1H)one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Methylsulfanyl)thieno[3,2-d]pyrimidin-4(1H)one(176530-46-4)
• EPA Substance Registry System: 2-(Methylsulfanyl)thieno[3,2-d]pyrimidin-4(1H)one(176530-46-4)

Safety Data

• Hazardous Substances Data: 176530-46-4(Hazardous Substances Data)

Usage

Class

Thienopyrimidines

Derivative

Thieno[3,2-d]pyrimidin-4(1H)-one

Potential applications

Pharmaceutical industry

Biological activities

Anti-cancer and anti-inflammatory properties

Structure

Heterocyclic compound with a thieno ring fused with a pyrimidine ring and a methylsulfanyl group attached to the thieno ring

Importance

Further research and development may lead to the discovery of new drugs with therapeutic benefits.

Upstream product

• 556-64-9 methyl thiocyanate 
• 22288-78-4 Methyl 3-aminothiophene-2-carboxylate 
• 31895-77-9 2-thioxo-2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-one 
• 77-78-1 dimethyl sulfate 
• 178675-17-7 methyl 3-[3-(1-phenylmethanoyl)thioureido]thiophene-2-carboxylate 
• 74-88-4 methyl iodide 

Downstream Products

• 1312701-30-6 (E)-2-(2-benzylidenehydrazinyl)thieno[3,2-d]pyrimidin-4(3H)-one 
• 1312701-31-7 (E)-2-(2-(4-chlorobenzylidene)hydrazinyl)thieno[3,2-d]pyrimidin-4(3H)-one 
• 1312701-32-8 (E)-2-(2-(4-methoxybenzylidene)hydrazinyl)thieno[3,2-d]pyrimidin-4(3H)-one 
• 1312701-33-9 (E)-2-(2-(4-bromobenzylidene)hydrazinyl)thieno[3,2-d]pyrimidin-4(3H)-one 
• 1312701-34-0 (E)-2-(2-(4-methylbenzylidene)hydrazinyl)thieno[3,2-d]pyrimidin-4(3H)-one 
• 1312701-35-1 (E)-2-(2-(3-chlorobenzylidene)hydrazinyl)thieno[3,2-d]pyrimidin-4(3H)-one 
• 1312701-36-2 (E)-2-(2-(3-bromobenzylidene)hydrazinyl)thieno[3,2-d]pyrimidin-4(3H)-one 
• 1312701-37-3 (E)-2-(2-(3-methylbenzylidene)hydrazinyl)thieno[3,2-d]pyrimidin-4(3H)-one 
• 1312701-46-4 1-phenylthieno[2,3-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one 
• 1312701-47-5 1-(4-chlorophenyl)thieno[2,3-e][1,2,4]triazolo[4,3-a]pyramidin-5(4H)-one 
• 1312701-48-6 1-(4-methoxyphenyl)thieno[2,3-e][1,2,4]triazolo[4,3-a]pyramidin-5(4H)-one 
• 1312701-49-7 1-(4-bromophenyl)thieno[2,3-e][1,2,4]triazolo[4,3-a]pyramidin-5(4H)-one 
• 1312701-50-0 1-p-tolylthieno[2,3-e][1,2,4]triazolo[4,3-a]pyramidin-5(4H)-one 
• 1312701-51-1 1-(3-chlorophenyl)thieno[2,3-e][1,2,4]triazolo[4,3-a]pyramidin-5(4H)-one 

Relevant articles and documents

SUBSTITUTED BICYCLIC PYRIMIDINE-BASED COMPOUNDS AND COMPOSITIONS AND USES THEREOF

Novel C-2-substituted bicyclic compounds of Formula I have been prepared and found to be useful as potent inhibitors of hGGPPS by inhibiting geranylgeranylation of proteins and inhibiting the biosynthesis of GGPP. The application is directed to these compounds, to compositions comprising these compounds, and to their use, in particular as medicaments for use in the treatment of cancer and other conditions which are treatable by inhibiting human geranylgeranylation pyrophosphate hGGPPS activity.

Synthesis of new 1-phenylthieno[1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one derivatives

A series of novel 1-phenylthieno[1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one derivatives 5 and 6 were synthesized by oxidative cyclization of thienopyrimidinonyl hydrazones using iodobenzene diacetate.