176530-46-4

Usage

Class

Thienopyrimidines

Derivative

Thieno[3,2-d]pyrimidin-4(1H)-one

Potential applications

Pharmaceutical industry

Biological activities

Anti-cancer and anti-inflammatory properties

Structure

Heterocyclic compound with a thieno ring fused with a pyrimidine ring and a methylsulfanyl group attached to the thieno ring

Importance

Further research and development may lead to the discovery of new drugs with therapeutic benefits.

Upstream product

• 31895-77-9 2-thioxo-2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-one 
• 77-78-1 dimethyl sulfate 
• 556-64-9 methyl thiocyanate 
• 22288-78-4 Methyl 3-aminothiophene-2-carboxylate 
• 178675-17-7 methyl 3-[3-(1-phenylmethanoyl)thioureido]thiophene-2-carboxylate 
• 74-88-4 methyl iodide 

Downstream Products

• 1353550-13-6 N-(3-((2-((4-(4-methylpiperazine-1-yl)phenyl)amino)thieno[3,2-d]pyrimidine-4-yl)oxy)phenyl)acrylamide 
• 1312701-53-3 1-m-tolylthieno[2,3-e][1,2,4]triazolo[4,3-a]pyramidin-5(4H)-one 
• 1312701-52-2 1-(3-bromophenyl)thieno[2,3-e][1,2,4]triazolo[4,3-a]pyramidin-5(4H)-one 
• 1312701-51-1 1-(3-chlorophenyl)thieno[2,3-e][1,2,4]triazolo[4,3-a]pyramidin-5(4H)-one 
• 1312701-50-0 1-p-tolylthieno[2,3-e][1,2,4]triazolo[4,3-a]pyramidin-5(4H)-one 
• 1312701-49-7 1-(4-bromophenyl)thieno[2,3-e][1,2,4]triazolo[4,3-a]pyramidin-5(4H)-one 
• 1312701-48-6 1-(4-methoxyphenyl)thieno[2,3-e][1,2,4]triazolo[4,3-a]pyramidin-5(4H)-one 
• 1312701-47-5 1-(4-chlorophenyl)thieno[2,3-e][1,2,4]triazolo[4,3-a]pyramidin-5(4H)-one 
• 1312701-46-4 1-phenylthieno[2,3-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one 
• 1312701-37-3 (E)-2-(2-(3-methylbenzylidene)hydrazinyl)thieno[3,2-d]pyrimidin-4(3H)-one 
• 1312701-36-2 (E)-2-(2-(3-bromobenzylidene)hydrazinyl)thieno[3,2-d]pyrimidin-4(3H)-one 
• 1312701-35-1 (E)-2-(2-(3-chlorobenzylidene)hydrazinyl)thieno[3,2-d]pyrimidin-4(3H)-one 
• 1312701-34-0 (E)-2-(2-(4-methylbenzylidene)hydrazinyl)thieno[3,2-d]pyrimidin-4(3H)-one 
• 1312701-33-9 (E)-2-(2-(4-bromobenzylidene)hydrazinyl)thieno[3,2-d]pyrimidin-4(3H)-one 

Relevant academic research and scientific papers

SUBSTITUTED BICYCLIC PYRIMIDINE-BASED COMPOUNDS AND COMPOSITIONS AND USES THEREOF

Novel C-2-substituted bicyclic compounds of Formula I have been prepared and found to be useful as potent inhibitors of hGGPPS by inhibiting geranylgeranylation of proteins and inhibiting the biosynthesis of GGPP. The application is directed to these compounds, to compositions comprising these compounds, and to their use, in particular as medicaments for use in the treatment of cancer and other conditions which are treatable by inhibiting human geranylgeranylation pyrophosphate hGGPPS activity.

NOVEL METHOD FOR PREPARING THIENOPYRIMIDINE COMPOUND AND INTERMEDIATES USED THEREIN

The present invention provides a novel method for preparing a thienopyrimidine compound of Formula 1, which is a selective inhibitor of tyrosine kinase activity, in particular, of mutant epidermal growth factor receptor tyrosine kinase, and novel intermediates used in the method.[ 1 ]

Synthesis of new 1-phenylthieno[1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one derivatives

A series of novel 1-phenylthieno[1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one derivatives 5 and 6 were synthesized by oxidative cyclization of thienopyrimidinonyl hydrazones using iodobenzene diacetate.