17654-38-5

Upstream product

• 6319-41-1 2-iso-propyl-4-thiocyanatophenol 
• 88-69-7 2-(1-methylethyl)phenol 

Downstream Products

• 131003-27-5 2-Bromo-4-p-fluorophenylthio-6-isopropylphenol 
• 131003-23-1 1-Benzyloxy-4-(p-fluorophenylthio)-2-isopropylbenzene 
• 131003-26-4 1-Benzyloxy-2-bromo-4-p-fluorophenylthio-6-isopropylbenzene 

Relevant academic research and scientific papers

Arylation of Phenols. Convenient, Regiospecific Methods for Mono- or Bis-p-fluorophenylations, Suitable for Large Scale Syntheses

Phenols have been arylated by a palladium(0)-catalyzed coupling reaction.Two methods were used: a Grignard reagent of a protected phenol component 2 was coupled with a haloarene, or an umpolung (reversed reactivity) where unprotected phenolic halides 6 were coupled with aryl Grignard reagents.Bis-arylation and regiospecific ortho-, meta- and para-arylations were achieved.Aryl-aryl-couplings were insensitive to steric hindrance in the Grignard component, but were inhibited by sulfur-containing substituents in the phenolic component.A thiocyanate substituted biaryl was used to synthesize arylated phenols with various sulfur functionalities.