6319-41-1

Upstream product

• 88-69-7 2-(1-methylethyl)phenol 
• 540-72-7 sodium thiocyanide 

Downstream Products

• 17654-38-5 2-Bromo-6-isopropyl-4-thiocyanatophenol 
• 131003-27-5 2-Bromo-4-p-fluorophenylthio-6-isopropylphenol 
• 131003-23-1 1-Benzyloxy-4-(p-fluorophenylthio)-2-isopropylbenzene 
• 131003-26-4 1-Benzyloxy-2-bromo-4-p-fluorophenylthio-6-isopropylbenzene 
• 1268500-66-8 2-{2-iso-propyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}-2-methylpropanoic acid 
• 1268500-64-6 2-{2-iso-propyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}propanoic acid 
• 1268500-62-4 2-{2-iso-propyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}acetic acid 
• 1268500-98-6 ethyl 2-{2-iso-propyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}-2-methylpropanoate 
• 1268500-96-4 ethyl 2-{2-iso-propyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}propanoate 
• 1268500-94-2 ethyl 2-{2-iso-propyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}acetate 
• 1268500-82-8 2-iso-propyl-4-{[4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl]methylthio}phenol 
• 1268500-77-1 2-iso-propyl-4-mercaptophenol 

Relevant academic research and scientific papers

Synthesis, biological evaluation and molecular modeling of GW 501516 analogues

Eleven analogues of GW 501516 (1) were prepared and subjected to biological testing in a semi-high throughput human skeletal muscle cell assay. The assay testing indicated that all analogues elicited oxidation of oleic acid. Among the most potent agonists, 2e (2-{2-ethyl-4-[(4-methyl-2-(4-trifluoromethylphenyl) thiazol-5-yl)methylthio]phenoxy}-2-methylpropanoic acid), was also subjected to a luciferase-based transfection assay, which showed that this compound is a potent agonist against PPARδ and a moderate agonist against PPARα. Docking of compound 2e into PPARδ revealed that it occupied the agonist binding site and exhibited key hydrogen bonding interactions with His323, His449, and Tyr473. Eleven GW 501516 analogues were prepared and subjected to human skeletal muscle cells. The assay testing indicated that all analogues elicited oxidation of oleic acid. One of the analogues displayed dual agonist effects against both PPARα and PPARδ. Copyright

Arylation of Phenols. Convenient, Regiospecific Methods for Mono- or Bis-p-fluorophenylations, Suitable for Large Scale Syntheses

Phenols have been arylated by a palladium(0)-catalyzed coupling reaction.Two methods were used: a Grignard reagent of a protected phenol component 2 was coupled with a haloarene, or an umpolung (reversed reactivity) where unprotected phenolic halides 6 were coupled with aryl Grignard reagents.Bis-arylation and regiospecific ortho-, meta- and para-arylations were achieved.Aryl-aryl-couplings were insensitive to steric hindrance in the Grignard component, but were inhibited by sulfur-containing substituents in the phenolic component.A thiocyanate substituted biaryl was used to synthesize arylated phenols with various sulfur functionalities.