176541-80-3Relevant academic research and scientific papers
IKCa-channel blockers. Part 2: Discovery of cyclohexadienes
Urbahns, Klaus,Goldmann, Siegfried,Krüger, Jochen,Horváth, Ervin,Schuhmacher, Joachim,Grosser, Rolf,Hinz, Volker,Mauler, Frank
, p. 401 - 404 (2007/10/03)
Novel cyclohexadienes have been identified as potent and specific IK Ca-channel blockers. In this communication we describe their synthesis as well as their chemical and biological properties. A selected derivative distributes well into brain and reduces the infarct volume, intracranial pressure as well as the water content in a rat subdural hematoma model of traumatic brain injury after iv administration. Novel cyclohexadienes have been identified as potent and specific IKCa-channel blockers. In this communication we describe their synthesis as well as their chemical and biological properties. A selected derivative is being enriched in rat brain and reduces the infarct volume, intracranial pressure as well as the water content in a rat subdural hematoma model of traumatic brain injury after iv administration.
Cyclohexadiene derivatives
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, (2008/06/13)
The cyclohexadiene derivatives are prepared by reaction of cyclohexanones with amines and subsequent dehydration. The compounds are suitable as active compounds in medicaments on account of their property of being selective modulators of calcium channel-d
