17656-57-4Relevant academic research and scientific papers
Transition metal-free Minisci reaction promoted by NCS, and TBHP: Acylation of heteroarenes
Siddaraju, Yogesh,Prabhu, Kandikere Ramaiah
supporting information, p. 959 - 967 (2016/02/03)
A method for acylation for heteroarenes under metal-free conditions has been described using NCS as an additive and TBHP as an oxidant. This method has been successfully employed in acylation of a variety of aldehyde with heteroarenes. The application of the method has been illustrated in synthesizing isoquinoline derived natural products. This strategy provides an efficient, mild and inexpensive method for acylation of heteroarenes.
A divergent approach to benzylisoquinoline-type and oxoaporphine alkaloids via regioselective direct ring metalation of alkoxy isoquinolines
Melzer, Benedikt,Bracher, Franz
, p. 7664 - 7672 (2015/07/15)
Methoxy- and benzyloxy-substituted isoquinolines are regioselectively metalated at C-1 with the Knochel-Hauser base, subsequent trapping with aromatic aldehydes gives aryl(isoquinolin-1-yl)carbinols as building blocks for divergent syntheses of different types of benzylisoquinoline alkaloids. Photochemical cyclization of ortho-bromo analogues under reductive conditions gives oxoaporphine alkaloids. Nine benzylisoquinoline alkaloids and two oxoaporphine alkaloids were obtained in two or three steps from appropriate isoquinolines.
Antiplatelet activity of benzylisoquinoline derivatives oxidized by cerium(IV) ammonium nitrate
Kuo, Reen-Yen,Chang, Fang-Rong,Wu, Chin-Chun,Patnam, Ramesh,Wang, Wei-Ya,Du, Ying-Chi,Wu, Yang-Chang
, p. 2789 - 2793 (2007/10/03)
Oxidation of 1-benzyl-3,4-dihydroisoquinolines with cerium(IV) ammonium nitrate (CAN) under mild condition yielded the mixture of corresponding 1-benzylisoquinolines (b-type) and 1-benzoylisoquinolines (a- or c-type) in an equal yields. The selective oxidation products (c-type) can be prepared by using MeCN instead of MeOH. In the antiplatelet assays, four inducers were employed, including AA, Col, PAF, and Thr. In the PAF or Col induced platelet aggregation, compounds belonging to a- and b-type showed stronger inhibitory effects than aspirin.
