176589-80-3

Upstream product

• 176589-79-0 C₄₀H₄₀O₁₀ 
• 98510-20-4 myo-Inositol orthoformate 
• 153325-42-9 4,6-di-O-benzoyl-myo-inositol 
• 153265-90-8 (-)-1D-1-O-butyryl-4,6-O-dibenzoyl-myo-inositol 
• 176589-78-9 1D-2-O-acetyl-1-O-butyryl-4,6-O-dibenzoyl-myo-inositol 

Relevant academic research and scientific papers

Enzyme assisted synthesis of D-myo-inositol-1,2,6-trisphosphate

The title compound is prepared in enantiomerically pure form via a facile enzyme assisted route. Essential for the success of the described method were a) the highly enantioselective esterification of 4,6-O-dibenzoyl-myo-inositol 2, b) the selective acylation of the axial hydroxyl function in 3 and c) the selective, base catalysed methanolysis of one benzoate group in 5. The obtained, selectively protected 1,2,6-triol 6 was converted into the title compound 7 by phosphorylation using N,N-dimethyl dibenzyl phosphoamidite followed by deprotection.