1766-63-8

Basic information

• Product Name: 1(2H)-Phthalazinone, 4-(4-fluorophenyl)-
• Synonyms: 1(2H)-Phthalazinone, 4-(4-fluorophenyl)-
• CAS NO: 1766-63-8
• Molecular Formula: C₁₄H₉FN₂O
• Molecular Weight: 240.24
• Mol File: 1766-63-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1(2H)-Phthalazinone, 4-(4-fluorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1(2H)-Phthalazinone, 4-(4-fluorophenyl)-(1766-63-8)
• EPA Substance Registry System: 1(2H)-Phthalazinone, 4-(4-fluorophenyl)-(1766-63-8)

Safety Data

• Hazardous Substances Data: 1766-63-8(Hazardous Substances Data)

Usage

General Description

1(2H)-Phthalazinone, 4-(4-fluorophenyl)-, also known as 4-(4-fluorophenyl)phthalazin-1(2H)-one, is a chemical compound with the molecular formula C14H8FNO. It is a white to off-white crystalline solid that is used in the synthesis of various pharmaceutical compounds as well as in research and development. 1(2H)-Phthalazinone, 4-(4-fluorophenyl)- is a phthalazinone derivative, and the 4-(4-fluorophenyl) substitution on the phthalazinone ring gives it unique chemical properties and biological activities. It is important to handle and use this compound with care, following all safety and regulatory guidelines, due to its potential hazards and risks associated with its handling and use in laboratory and industrial settings.

Upstream product

• 610-97-9 o-iodo-methyl-benzoic acid 
• 341-57-1 methyl 2-(4-fluorobenzoyl)benzoate 
• 459-57-4 4-fluorobenzaldehyde 
• 4752-10-7 1,4-dichlorophthalazine 
• 2257-69-4 1-chloro-4-phthalazinone 
• 1765-93-1 4-fluoroboronic acid 
• 7649-92-5 2-(4-fluorobenzoyl)benzoic acid 

Downstream Products

• 1354719-90-6 4-(4-fluorophenyl)-2-[3-[4-[3-(acetylamino)phenyl]piperidin-1-yl]propyl]phthalazin-1(2H)-one 
• 1354720-49-2 4-(4-fluorophenyl)-2-(3-chloropropyl)phthalazin-1(2H)-one 

Relevant articles and documents

Pyridazinone compound, preparation method thereof, pharmaceutical composition and application thereof

The invention relates to a pyridazinone compound shown as a formula I or an isomer thereof, or a pharmaceutically acceptable salt, ester, a prodrug or a solvate thereof, a preparation method thereof,a pharmaceutical composition and an application of the pharmaceutical composition for preparing a dengue virus inhibitor. The pyridazinone compound has a structure shown in the formula I. The compoundor the pharmaceutical composition thereof has anti-dengue virus activity and better selectivity, and can be used for preventing and/or treating dengue virus infection.

Discovery and optimization of phthalazinone derivatives as a new class of potent dengue virus inhibitors

Using a dengue replicon cell line-based screening, we identified 3-(dimethylamino)propyl(3-((4-(4-fluorophenyl)-1-oxophthalazin-2(1H)-yl)methyl)phenyl)carbamate (10a) as a potent DENV-2 inhibitor, with an IC50 value of 0.64 μM. A series of novel phthalazinone derivatives based on hit 10a were synthesized and evaluated for their in vitro anti-DENV activity and cytotoxicity. The subsequent SAR study and optimization led to the discovery of the most promising compound 14l, which displayed potent anti-DENV-2 activity, with low IC50 value against DENV-2 RNA replication of 0.13 μM and high selectivity (SI = 89.2) with acceptable pharmacokinetics profiles.