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2257-69-4

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2257-69-4 Usage

Uses

1-Chlorophthalazin-4-one acts as an organic and pharmaceutical intermediate.

Check Digit Verification of cas no

The CAS Registry Mumber 2257-69-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,2,5 and 7 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 2257-69:
(6*2)+(5*2)+(4*5)+(3*7)+(2*6)+(1*9)=84
84 % 10 = 4
So 2257-69-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H5ClN2O/c9-7-5-3-1-2-4-6(5)8(12)11-10-7/h1-4H,(H,11,12)

2257-69-4 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (H27515)  1-Chlorophthalazin-4-one, 98%   

  • 2257-69-4

  • 250mg

  • 165.0CNY

  • Detail
  • Alfa Aesar

  • (H27515)  1-Chlorophthalazin-4-one, 98%   

  • 2257-69-4

  • 1g

  • 420.0CNY

  • Detail
  • Alfa Aesar

  • (H27515)  1-Chlorophthalazin-4-one, 98%   

  • 2257-69-4

  • 5g

  • 1302.0CNY

  • Detail

2257-69-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-chloro-2H-phthalazin-1-one

1.2 Other means of identification

Product number -
Other names 4-chlorophthalazin-1-ol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2257-69-4 SDS

2257-69-4Relevant articles and documents

Discovery of Phthalazinone Derivatives as Novel Hepatitis B Virus Capsid Inhibitors

Chen, Wuhong,Liu, Feifei,Zhao, Qiliang,Ma, Xinna,Lu, Dong,Li, Heng,Zeng, Yanping,Tong, Xiankun,Zeng, Limin,Liu, Jia,Yang, Li,Zuo, Jianping,Hu, Youhong

, p. 8134 - 8145 (2020)

HBV capsid assembly has been viewed as an attractive target for new antiviral therapies against HBV. On the basis of a lead compound 4r, we further investigated this target to identify novel active compounds with appropriate anti-HBV potencies and improved pharmacokinetic (PK) properties. Structure-activity relationship studies based on metabolic pathways of 4r led to the identification of a phthalazinone derivative 19f with appropriate anti-HBV potencies (IC50 = 0.014 ± 0.004 μM in vitro), which demonstrated high oral bioavailability and liver exposure. In the AAV-HBV/mouse model, administration of 19f resulted in a 2.67 log reduction of the HBV DNA viral load during a 4-week treatment with 150 mg/kg dosing twice daily.

TOLL-LIKE RECEPTOR 8 (TLR8)-SPECIFIC ANTAGONISTS AND METHODS OF MAKING AND USES THEREOF

-

Page/Page column 52, (2019/05/22)

Toll-like receptor 8 (TLR8)-specific inhibitors and methods of using the same in individuals having an autoimmune disease or an inflammatory disorder.

Pyridazinone compound, preparation method thereof, pharmaceutical composition and application thereof

-

Paragraph 0092-0094, (2019/03/15)

The invention relates to a pyridazinone compound shown as a formula I or an isomer thereof, or a pharmaceutically acceptable salt, ester, a prodrug or a solvate thereof, a preparation method thereof,a pharmaceutical composition and an application of the pharmaceutical composition for preparing a dengue virus inhibitor. The pyridazinone compound has a structure shown in the formula I. The compoundor the pharmaceutical composition thereof has anti-dengue virus activity and better selectivity, and can be used for preventing and/or treating dengue virus infection.

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