17663-63-7Relevant academic research and scientific papers
Preparation method of tenuazonic Acid and derivative thereof
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Paragraph 0097-0098, (2021/05/12)
The invention provides a preparation method of tenuazonic Acid and a derivative thereof. The synthesis route comprises the following steps: reacting malonic acid cycloisopropylidene ester with acyl chloride, then reacting with amino acid methyl ester hydr
Total synthesis of tyrosine-derived tetramic acid pigments from a slime mould
Riache, Nassima,Bailly, Christine,Deville, Alexandre,Dubost, Lionel,Nay, Bastien
experimental part, p. 5402 - 5408 (2010/11/18)
A method for the total synthesis of naturally occurring 3-enoyltetramic acids derived from L-tyrosine is described, allowing for three chemical transformations to occur in one pot by using a multicomponent mixture, The sequence involves (1) a base-promoted Lacey-Dieckmann condensation, (2) a Michaelis-Becker reaction, and (3) a Wittig-Horner-Emmons reaction between the resulting 3-phosphonoacetyltetramic acid and an appropriate aldehyde. This sequence of reactions was applied to the synthesis of polyenic pigments obtained from the slime mould Leocarpus fragilis starting from readily available precursors. A series of structurally related compounds was also synthesized and their antibiotic significance was evaluated to elucidate their role in nature.
