176640-48-5Relevant articles and documents
Solid phase synthesis and purification of 5′-mercaptoalkylated oligonucleotides
Kumar,Bhatia,Rastogi,Gupta
, p. 683 - 688 (1996)
A novel strategy for the synthesis of thiol link phosphoramidites having base labile S-acyl type protecting groups is described. The method involves the reaction of 6-bromohexanol with potassium thioacetate or thiobenzoate in the presence of 18-crown-6 as a phase transfer catalyst to obtain the compounds 3(a,b), which were then converted to their corresponding phosphoramidites 4(a,b) and used for solid phase synthesis of 5′-mercaptoalkylated oligonucleotides. The thiolated oligomers were purified by single step covalent chromatography using an activated sulfhydryl group containing support.
Microwave assisted synthesis of S-trityl and S-acylmercaptoalkanols, nucleosides and their deprotection
Kumar,Gupta
, p. 635 - 636 (2007/10/03)
Simple and high yielding methods for the synthesis and deprotection of S-trityl and S-acylhexanols and appropriately protected 2'-deoxynucleosides in solvent and dry media conditions are described which occur under mild conditions using microwave irradiation.
