17665-02-0

Usage

Uses

Used in Pharmaceutical Research and Development:
H-LEU-D-LEU-OH is used as a biochemical tool for studying protein interactions and metabolism, aiding in the understanding of leucine's role in various biological processes.
Used in Drug Development:
H-LEU-D-LEU-OH is used as a potential component in the development of new drugs, leveraging its properties to target specific therapeutic areas, such as muscle growth, blood sugar regulation, or immune function enhancement.
Used in Biochemical Research:
H-LEU-D-LEU-OH is used as a research compound to explore the effects of dipeptides on protein synthesis and to investigate their potential as therapeutic agents for various diseases and conditions.
Used in Nutritional Supplements:
H-LEU-D-LEU-OH may be used as an ingredient in nutritional supplements designed to support muscle growth, enhance athletic performance, and improve overall health by providing a readily available source of essential amino acids.
Used in Cosmetics and Personal Care:
H-LEU-D-LEU-OH could be incorporated into cosmetic and personal care products for its potential skin health benefits, such as promoting collagen synthesis and improving skin elasticity.

InChI:InChI=1/C12H24N2O3/c1-7(2)5-9(13)11(15)14-10(12(16)17)6-8(3)4/h7-10H,5-6,13H2,1-4H3,(H,14,15)(H,16,17)/t9-,10+/m0/s1

Upstream product

• 2883-36-5 L-Leu-Leu 
• 71730-80-8 Z-L-Leu-D-Leu-OMe 
• 35661-60-0 Fmoc-Leu-OH 
• 35661-60-0 N-(9-fluorenylmethoxycarbonyl)-D-leucine 
• 76863-45-1 (S)-benzyl (1-azido-4-methyl-1-oxopentan-2-yl)carbamate 
• 23032-21-5 D-leucine methyl ester 
• 184684-49-9 N-(N-benzyloxycarbonyl-L-leucyl)-D-leucine 

Downstream Products

• 328-38-1 (R)-leucine 
• 61-90-5 L-leucine 
• 3303-31-9 L-leucyl-L-leucine 

Relevant academic research and scientific papers

Champacyclin, a new cyclic octapeptide from Streptomyces strain C42 isolated from the Baltic Sea

New isolates of Streptomyces champavatii were isolated from marine sediments of the Gotland Deep (Baltic Sea), from the Urania Basin (Eastern Mediterranean), and from the Kiel Bight (Baltic Sea). The isolates produced several oligopeptidic secondary metabolites, including the new octapeptide champacyclin (1a) present in all three strains. Herein, we report on the isolation, structure elucidation and determination of the absolute stereochemistry of this isoleucine/leucine (Ile/Leu = Xle) rich cyclic octapeptide champacyclin (1a). As 2D nuclear magnetic resonance (NMR) spectroscopy could not fully resolve the structure of (1a), additional information on sequence and configuration of stereocenters were obtained by a combination of multi stage mass spectrometry (MSn) studies, amino acid analysis, partial hydrolysis and subsequent enantiomer analytics with gas chromatography positive chmical ionization/electron impact mass spectrometry (GC-PCI/EI-MS) supported by comparison to reference dipeptides. Proof of the head-to-tail cyclization of (1a) was accomplished by solid phase peptide synthesis (SPPS) compared to an alternatively side chain cyclized derivative (2). Champacyclin (1a) is likely synthesized by a non-ribosomal peptide synthetase (NRPS), because of high content of (D)-amino acids. The compound (1a) showed antimicrobial activity against the phytopathogen Erwinia amylovora causing the fire blight disease of certain plants.