H-LEU-D-LEU-OH

Base Information

• Chemical Name: H-LEU-D-LEU-OH
• CAS No.: 17665-02-0
• Molecular Formula: C12H24 N2 O3
• Molecular Weight: 244.334
• Hs Code.: 2924199090
• Mol file: 17665-02-0.mol

Synonyms:D-Leucine,N-L-leucyl-; Leucine, N-L-leucyl-, D- (8CI); L-Leucyl-D-leucine;Leucyl-D-leucine

Chemical Property of H-LEU-D-LEU-OH

Chemical Property:

• Vapor Pressure: 1.07E-08mmHg at 25°C
• Refractive Index: 1.481
• Boiling Point: 432.7oC at 760 mmHg
• Flash Point: 215.5oC
• PSA: 92.42000
• Density: 1.051g/cm3
• LogP: 2.06650
• Storage Temp.: −20°C
• Solubility.: Aqueous Acid (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

L-Leucyl-D-leucine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-LEU-D-LEU-OH

There total 6 articles about H-LEU-D-LEU-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-Leu-Leu (2883-36-5,3272-06-8,3303-31-9,3304-63-0,17665-02-0,38689-30-4,38689-31-5) → L-leucyl-L-leucine (3303-31-9) + L-leucyl-D-leucine (17665-02-0)

Guidance literature:

With (2S,4R,2'RS)-N-(2-hydroxy-dodecyl)-4-hydroxy-proline; water; In methanol; acetonitrile; separation with DC, further dipeptides, also enantiomeric dipeptides, R_f-values;

Reference yield:

Fmoc-Leu-OH (35661-60-0) + N-(9-fluorenylmethoxycarbonyl)-D-leucine (35661-60-0,126727-03-5,114360-54-2) → L-leucyl-D-leucine (17665-02-0)

Guidance literature:

N-(9-fluorenylmethoxycarbonyl)-D-leucine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h;

With N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;

Fmoc-Leu-OH; Further stages;

DOI:10.3390/md11124834

Reference yield:

N-(N-benzyloxycarbonyl-L-leucyl)-D-leucine (184684-49-9) → L-leucyl-D-leucine (17665-02-0)

Guidance literature:

With methanol; palladium; acetic acid; Hydrogenation;

DOI:10.1021/jo01147a018

upstream raw materials:

N-(N-benzyloxycarbonyl-L-leucyl)-D-leucine

L-Leu-Leu

D-leucine methyl ester

Z-L-Leu-D-Leu-OMe

Downstream raw materials:

L-leucyl-L-leucine

(R)-leucine

L-leucine

Refernces

• 1、 Pesic, Alexander,Baumann, Heike I.,Kleinschmidt, Katrin,Ensle, Paul,Wiese, Jutta,Suessmuth, Roderich D.,Imhoff, Johannes F.. "Champacyclin, a new cyclic octapeptide from Streptomyces strain C42 isolated from the Baltic Sea". . p. 4834 - 4857. Retrieved 2014/02/14.