176652-03-2

Basic information

• Product Name: methyl 4-azido-3-iodobenzoate
• Synonyms: methyl 4-azido-3-iodobenzoate
• CAS NO: 176652-03-2
• Molecular Weight: 303.059
• Mol File: 176652-03-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl 4-azido-3-iodobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-azido-3-iodobenzoate(176652-03-2)
• EPA Substance Registry System: methyl 4-azido-3-iodobenzoate(176652-03-2)

Safety Data

• Hazardous Substances Data: 176652-03-2(Hazardous Substances Data)

Upstream product

• 619-45-4 4-methoxycarbonyl aniline 
• 19718-49-1 4-amino-3-iodobenzoic acid methyl ester 

Downstream Products

• 167868-39-5 C₅₇H₈₁IN₄O₁₃ 
• 167868-43-1 4-azido-3-iodobenzyl alcohol 
• 140430-71-3 4-azido-3-iodobenzoic acid 

Relevant articles and documents

Unprecedented synthesis of 1,2,3-triazolo-cinnolinone via Sonogashira coupling and intramolecular cyclization

An unprecedented copper mediated one-pot sequential synthesis of 1,2,3-triazolo cinnolinone derivatives from 2-halo-phenyl triazoles and terminal alkynes has been reported. Under the optimized reaction conditions, a broad range of substituted triazoles and alkynes were found to participate in this transformation, thus affording unknown 1,2,3-triazolo cinnolinone derivatives in moderate to excellent yields. This method proceeds through sequential C-C coupling followed by an annulation cascade sequence in the same vessel under atmospheric air as the sole oxidant, thus representing a simple, efficient and atom economical approach for the synthesis of aza-cinnolinones.

Synthesis of I-125 labeled photoaffinity rapamycin analogs

Two no-carrier-added 125I-labeled photoaffinity rapamycin analogs were prepared: 7-demethoxy-7-(4-azido-3-125I-benzyloxy)rapamycin (2) and its C28-C29 seco analog 3. The key reactions of the synthesis were subst