176652-03-2Relevant academic research and scientific papers
Unprecedented synthesis of 1,2,3-triazolo-cinnolinone via Sonogashira coupling and intramolecular cyclization
Kumar, Avnish,Tiwari, Dharmendra Kumar,Sridhar, Balasubramanian,Likhar, Pravin R.
, p. 4840 - 4848 (2018)
An unprecedented copper mediated one-pot sequential synthesis of 1,2,3-triazolo cinnolinone derivatives from 2-halo-phenyl triazoles and terminal alkynes has been reported. Under the optimized reaction conditions, a broad range of substituted triazoles and alkynes were found to participate in this transformation, thus affording unknown 1,2,3-triazolo cinnolinone derivatives in moderate to excellent yields. This method proceeds through sequential C-C coupling followed by an annulation cascade sequence in the same vessel under atmospheric air as the sole oxidant, thus representing a simple, efficient and atom economical approach for the synthesis of aza-cinnolinones.
Cu(I)-catalyzed cascade intramolecular cyclization of 2-propynol phenyl azides and diarylphosphine oxides for the synthesis of bisphosphorylated indole derivatives
Song, Xian-Rong,Li, Ren,Yang, Tao,Bai, Jiang,Yang, Ruchun,Chen, Xi,Ding, Haixin,Xiao, Qiang,Liang, Yong-Min
supporting information, p. 3763 - 3766 (2018/09/12)
The [Cu(OTf)]2·C6H6 catalyzed cascade intermolecular addition–intramolecular cyclization reaction of easily prepared 2-propynol phenyl azides and diarylphosphine oxides was developed. This novel reaction leads to simultane
Synthesis of I-125 labeled photoaffinity rapamycin analogs
Shu, Arthur Y.L.,Yamashita, Dennis S.,Holt, Dennis A.,Heys, J. Richard
, p. 227 - 237 (2007/10/03)
Two no-carrier-added 125I-labeled photoaffinity rapamycin analogs were prepared: 7-demethoxy-7-(4-azido-3-125I-benzyloxy)rapamycin (2) and its C28-C29 seco analog 3. The key reactions of the synthesis were subst
