176656-40-9

Basic information

• Product Name: C₆₆H₁₀₁NO₁₁Si₂
• Synonyms: C₆₆H₁₀₁NO₁₁Si₂
• CAS NO: 176656-40-9
• Molecular Weight: 1140.7
• Mol File: 176656-40-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₆₆H₁₀₁NO₁₁Si₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₆₆H₁₀₁NO₁₁Si₂(176656-40-9)
• EPA Substance Registry System: C₆₆H₁₀₁NO₁₁Si₂(176656-40-9)

Safety Data

• Hazardous Substances Data: 176656-40-9(Hazardous Substances Data)

Downstream Products

• 104987-11-3 Tacrolimus 

Relevant articles and documents

A total synthesis of FK-506

A total synthesis of FK-506 (1) is presented. The synthesis features a highly convergent approach utilizing a block coupling strategy. Top and bottom half sections of the molecule are coupled by addition of a vinyl cuprate with a spiroenone. The α-allyl aldol functionality is revealed by a reductive opening of the spiroenone system. The labile α,β-diketoamide hemiketal portion of the molecule is prepared by a late stage generation and oxidation of a masked enediol. Top and bottom half segments are themselves derived by coupling of smaller subunits, resulting in a very convergent route.