176671-74-2Relevant articles and documents
Estrogen mimetics lacking reproductive tract effects
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, (2008/06/13)
A method for treating symptoms, diseases and conditions in extra-reproductive tract tissues that are responsive to treatment with estrogen, using triarylethanes of formula (I) wherein R1is —O(CH2)mR3or —(CH2)nR3; wherein R3is an anionic substituent; m is an integer from 1 to 4; and n is an integer from 0 to 4; and wherein R2is either H or —OH. Each of R1and R2can be either meta or para to its respective phenyl ethyl linkage. Compounds having the formula (I) wherein R1is —O(CH2)mR3or —(CH2)nR3; R3is an anionic substituent; m is 1, 2, 3 or 4; n is 0, 1, 2, 3 or 4; R2is H or —OH; and wherein each of R1and R2is independently meta or para to its respective phenyl ethyl linkage are also provided, with the proviso that R2is not para —OH when m is 1 and R3is —COOH.