176692-14-1

Basic information

• Product Name: 3-[2-(Tetrahydro-pyran-2-yloxymethyl)-phenyl]-propionaldehyde
• Synonyms: 3-[2-(Tetrahydro-pyran-2-yloxymethyl)-phenyl]-propionaldehyde
• CAS NO: 176692-14-1
• Molecular Weight: 248.322
• Mol File: 176692-14-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-[2-(Tetrahydro-pyran-2-yloxymethyl)-phenyl]-propionaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[2-(Tetrahydro-pyran-2-yloxymethyl)-phenyl]-propionaldehyde(176692-14-1)
• EPA Substance Registry System: 3-[2-(Tetrahydro-pyran-2-yloxymethyl)-phenyl]-propionaldehyde(176692-14-1)

Safety Data

• Hazardous Substances Data: 176692-14-1(Hazardous Substances Data)

Upstream product

• 88-67-5 2-Iodobenzoic acid 
• 1196708-16-3 C₁₅H₂₂O₃ 
• 5159-41-1 2-iodobenzyl alcohol 
• 110-87-2 3,4-dihydro-2H-pyran 

Downstream Products

• 1196708-17-4 C₁₆H₂₂O₂ 
• 121089-46-1 (2-(but-3-en-1-yl)phenyl)methanol 

Relevant articles and documents

Terminal olefins to chromans, isochromans, and pyrans via allylic C-H oxidation

The synthesis of chroman, isochroman, and pyran motifs has been accomplished via a combination of Pd(II)/bis-sulfoxide C-H activation and Lewis acid co-catalysis. A wide range of alcohols are found to be competent nucleophiles for the transformation under uniform conditions (catalyst, solvent, temperature). Mechanistic studies suggest that the reaction proceeds via initial C-H activation followed by a novel inner-sphere functionalization pathway. Consistent with this, the reaction shows reactivity trends orthogonal to those of traditional Pd(0)-catalyzed allylic substitutions.

Diastereoselektive chelatkontrollierte Radikalcyclisierung eines chiralen, von Oxazolidinon abgeleiteten 2-Alkenamids und Modellierung des Uebergangszustands dieser Reaktion

Keywords: Asymmetrische Synthesen; Kraftfeldrechnungen; Oxazolidinone; Radikale; Tetraline