17671-75-9

Basic information

• Product Name: 5-BENZYLOXY-2-BROMOTOLUENE
• Synonyms: 1-BROMO-4-BENZOXY-2-METHYL-BENZENE;5-BENZYLOXY-2-BROMOTOLUENE;4-(BENZYLOXY)-1-BROMO-2-METHYLBENZENE;4-(BENZYLOXY)-2-METHYL BROMO BENZENE;Benzene, 1-bromo-2-methyl-4-(phenylmethoxy)-;1-bromo-2-methyl-4-phenylmethoxybenzene
• CAS NO: 17671-75-9
• Molecular Formula: C₁₄H₁₃BrO
• Molecular Weight: 277.16
• Product Categories: Aromatic Hydrocarbons (substituted) & Derivatives;Anisoles, Alkyloxy Compounds & Phenylacetates;Bromine Compounds
• Mol File: 17671-75-9.mol
• Article Data: 13

Chemical Properties

• Melting Point: 69-70.5°C
• Boiling Point: 360.904 °C at 760 mmHg
• Flash Point: 146.654 °C
• Appearance: /
• Density: 1.342 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-BENZYLOXY-2-BROMOTOLUENE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BENZYLOXY-2-BROMOTOLUENE(17671-75-9)
• EPA Substance Registry System: 5-BENZYLOXY-2-BROMOTOLUENE(17671-75-9)

Safety Data

• Hazardous Substances Data: 17671-75-9(Hazardous Substances Data)

Usage

General Description

5-BENZYLOXY-2-BROMOTOLUENE, also known as benzyloxy-bromotoluene, is a chemical compound with the molecular formula C14H13BrO. It is a white to light yellow crystalline solid that is commonly used as an intermediate in organic synthesis. 5-BENZYLOXY-2-BROMOTOLUENE is primarily used in the production of pharmaceuticals, agrochemicals, and other specialty chemicals. It is known for its aromatic properties and is often used as a starting material in the synthesis of various organic compounds. Additionally, 5-BENZYLOXY-2-BROMOTOLUENE is a versatile building block in organic chemistry and has applications in research and development of new materials. However, it is important to handle this compound with care and use appropriate safety measures due to its potential hazards and health risks.

Upstream product

• 100-39-0 benzyl bromide 
• 14472-14-1 4-bromo-3-methylphenol 

Downstream Products

• 101093-56-5 4-benzyloxy-2-methyl-benzaldehyde 
• 167479-46-1 4-benzyloxy-2-methylphenylmethanol 
• 175153-40-9 methyl 4-benzyloxy-2-methylbenzoate 
• 1609259-87-1 5-(4-hydroxy-2-methylphenyl)-4-methyl-2-(tetrahydro-2H-pyran-2-yl)pyridazin-3(2H)-one 

Relevant articles and documents

Synthesis and Pharmacological Evaluation of Noncatechol G Protein Biased and Unbiased Dopamine D1 Receptor Agonists

Noncatechol heterocycles have recently been discovered as potent and selective G protein biased dopamine 1 receptor (D1R) agonists with superior pharmacokinetic properties. To determine the structure-activity relationships centered on G protein or β-arrestin signaling bias, systematic medicinal chemistry was employed around three aromatic pharmacophores of the lead compound 5 (PF2334), generating a series of new molecules that were evaluated at both D1R Gs-dependent cAMP signaling and β-arrestin recruitment in HEK293 cells. Here, we report the chemical synthesis, pharmacological evaluation, and molecular docking studies leading to the identification of two novel noncatechol D1R agonists that are a subnanomolar potent unbiased ligand 19 (PW0441) and a nanomolar potent complete G protein biased ligand 24 (PW0464), respectively. These novel D1R agonists provide important tools to study D1R activation and signaling bias in both health and disease.

[...] compd. mesogene medium

The invention relates to bimesogenic compounds of formula I wherein R11, R12, MG11, MG12, X11, X12 and Sp1 have the meaning given in claim 1, to the use of bimesogenic compounds of formula I in liquid crystal media and particular to flexoelectric liquid crystal devices comprising a liquid crystal medium according to the present invention.

l , l , 3-TRI0X0-l , 2 , 5-THIADIAZ0LIDINES AND THEIR USE AS PTP-ASES INHIBITORS

Compounds of the formula are inhibitors of protein tyrosine phosphatases (PTPases) and, thus, may be employed for the treatment of conditions mediated by PTPase activity. The compounds of the present invention may also be employed as inhibitors of other e