17672-88-7Relevant articles and documents
Antioxidant Activity of Natural Allylpolyalkoxybenzene Plant Essential Oil Constituents
Samet, Alexander V.,Shevchenko, Oksana G.,Rusak, Vyacheslav V.,Chartov, Eduard M.,Myshlyavtsev, Andrey B.,Rusanov, Daniil A.,Semenova, Marina N.,Semenov, Victor V.
, p. 1451 - 1458 (2019/07/05)
Free-radical-scavenging capacity antioxidant and membrane-protective properties of natural and related synthetic allylpolyalkoxybenzenes with different numbers of alkoxy/methoxy groups in the aromatic ring were evaluated using several in vitro models. These included the DPPH assay, inhibition of lipid peroxidation products accumulation, inhibition of H2O2-induced hemolysis, and oxidation of oxyhemoglobin. A synthetic protocol for the synthesis of natural nothoapiol (9) from a parsley seed metabolite, apiol (7), was developed. A structure-activity relationship study revealed that both the methylenedioxy fragment and methoxy groups in the aromatic ring are favorable for antioxidant activity. Hydroxyapiol (14), containing a hydroxy group in the aromatic core, was identified as the most potent compound. The pentaalkoxy-substituted nothoapiol (9) showed antioxidant activity in mouse brain homogenates, whereas in mouse erythrocytes it exhibited a marked pro-oxidant effect. Despite their low free-radical-scavenging capacity, allylpolyalkoxybenzenes can contribute to the total antioxidant potencies of plant essential oils.
