176729-59-2Relevant academic research and scientific papers
Synthesis and reactivity of 2-thionoester pyrroles: A route to 2-formyl pyrroles
Kim, Min Joon,Gaube, Sophie M.,Beh, Michael H. R.,Smith, Craig D.,Thompson, Alison
, p. 31773 - 31780 (2019/10/19)
2-Functionalised pyrroles exhibit considerable synthetic utility. Herein, the synthesis and reactivity of 2-thionoester (-C(S)OR) pyrroles is reported. 2-Thionoester pyrroles were synthesised using a Knorr-type approach from aliphatic starting materials. 2-Thionoester pyrroles were reduced to the corresponding 2-formyl pyrroles, or the deuterated formyl variant, in one step using RANEY nickel, thereby removing the need for the much-utilised hydrolysis/decarboxylation/formylation steps that are typically required to convert Knorr-type 2-carboxylate pyrroles into 2-formyl pyrroles. 2-Thionoester pyrroles proved tolerant of typical functional group interconversions for which the parent 2-carboxylate pyrroles have become known.
An efficient transesterification of β-oxodithioesters catalyzed by stannous chloride under solvent-free conditions
Devi, Nepram Sushuma,Singh, Sarangthem Joychandra,Singh, Okram Mukherjee
, p. 1432 - 1435 (2013/05/08)
Transesterification of β-oxodithioesters catalyzed by stannous chloride under solvent-free condition has been reported for the first time. The short reaction time and good to excellent yields using inexpensive catalysts are attractive features of this synthetic protocol. Copyright
GLYCOPYRANOSYLOXYPYRAZOLE DERIVATIVES AND MEDICINAL USE THEREOF
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Page/Page column 15, (2010/02/07)
The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R1, R2 and R3 represent a hydrogen atom or a halogen atom; R4 represents a lower alkyl group or a halo(lower alkyl) group; and R5 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, etc., a pharmaceutically acceptable salt thereof or a prodrug thereof., which exert an excellent inhibitory activity in human SGLT2, and therefore are useful as drugs for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, pharmaceutically acceptable salts thereof or prodrugs thereof, production intermediates thereof and pharmaceutical uses thereof.
Thermal cycloreversion of 4H-1,3-dioxine-4-thiones to acyl thioketenes: A general synthesis of β-keto thioic O-acid derivatives
Sato, Masayuki,Ban, Hitoshi,Uehara, Fumiaki,Kaneko, Chikara
, p. 775 - 776 (2007/10/03)
Thermal cycloreversion of 4H-1,3-dioxine-4-thiones gives acyl thioketenes as reactive intermediates, trapping of which by nucleophiles provides a general synthesis for β-keto thioic O-acid derivatives.
