176755-40-1

Basic information

• Product Name: (S)-4-Cyclohexylcarbamoyl-3-hydroxy-3-methyl-butyric acid methyl ester
• CAS NO: 176755-40-1
• Molecular Weight: 257.33
• Mol File: 176755-40-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-4-Cyclohexylcarbamoyl-3-hydroxy-3-methyl-butyric acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-Cyclohexylcarbamoyl-3-hydroxy-3-methyl-butyric acid methyl ester(176755-40-1)
• EPA Substance Registry System: (S)-4-Cyclohexylcarbamoyl-3-hydroxy-3-methyl-butyric acid methyl ester(176755-40-1)

Safety Data

• Hazardous Substances Data: 176755-40-1(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 108-91-8 cyclohexylamine 
• 176755-33-2 ((R)-2-Methyl-4-oxo-oxetan-2-yl)-acetic acid 
• 503-49-1 meglutol 
• 34695-32-4 3-hydroxy-3-methylglutaric anhydride 

Relevant articles and documents

A new reagent for the preparation of chiral HMGA (3-hydroxy-3-methylglutaric acid) esters and amides. Synthesis of (R)- and (S) -β-carboxymethyl-β-methyl-β-lactones by asymmetric desymmetrization of HMGA anhydride

(R)- and (S)-βarboxymethyl-β-methyl-β-lactones, new reagents for the preparation of chiral HMGA (3-hydroxy-3-methylglutaric acid) esters and amides were developed through the asymmetric desymmetrization of HMGA anhydride. The reagent was smoothly reactedwith various alkoxide without racemization to afford the desirable half-esters. On the other hand, the reaction with various amine in refluxing toluene gave a racemic amide. The chiral HMGA amide was prepared using the corresponding methyl ester of the reagent.