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503-49-1

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503-49-1 Usage

Description

Meglutol (β-hydroxy-β-methylglutaric acid; HMG) is a hypolipidemic agent that acts via the inhibition of cholesterol synthesis a t the stage of HMG-CoAreductase, blocking the conversion of HMG-CoA to mevalonate. This conversion is the rate-limiting step in cholesterol biosynthesis and is the point of physiological feedback control; as such, it appears to be the ideal locus of action for a hypolipidemic agent. Investigational compounds that act by this mechanism include the natural products compactin and mevinolin.

Chemical Properties

White Solid

Originator

Aligarh Muslim Univ. (India)

Uses

Different sources of media describe the Uses of 503-49-1 differently. You can refer to the following data:
1. antihyperlipoproteinemia
2. 3-Hydroxy-3-methylpentane-1,5-dioic Acid (cas# 503-49-1) is a compound useful in organic synthesis.

Definition

ChEBI: A dicarboxylic acid that is glutaric acid in which one of the two hydrogens at position 3 is substituted by a hydroxy group, while the other is substituted by a methyl group. It has been found to accumulate in urine of patients suffering from HMG-CoA lyase (3-hydroxy-3-methylglutaryl-CoA lyase, EC 4.1.3.4) deficiency. It occurs as a plant metabolite in Crotalaria dura.

Brand name

LIPOGLUTAREN

Synthesis Reference(s)

Synthesis, p. 791, 1981 DOI: 10.1055/s-1981-29596

Purification Methods

Recrystallise the acid from diethyl ether/hexane and dry it under avacuum at 60o for 1hour. [Beilstein 3 IV 1166.]

Check Digit Verification of cas no

The CAS Registry Mumber 503-49-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,0 and 3 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 503-49:
(5*5)+(4*0)+(3*3)+(2*4)+(1*9)=51
51 % 10 = 1
So 503-49-1 is a valid CAS Registry Number.
InChI:InChI=1/C6H10O5/c7-3-4(1-5(8)9)2-6(10)11/h4,7H,1-3H2,(H,8,9)(H,10,11)

503-49-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-hydroxy-3-methylglutaric acid

1.2 Other means of identification

Product number -
Other names 3-Hydroxy-3-Methylglutaric Acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:503-49-1 SDS

503-49-1Relevant articles and documents

-

Klostermann,Smith

, p. 1229 (1954)

-

SYNTHESIS OF MEVALONOLACTONE FROM 4-(β-HYDROXYETHYL)-4-METHYL-1,3-DIOXANE

Sargsyan, M. S.,Manukyan, A. T.,Mkrtumyan, S. A.,Gevorkyan, A. A.

, p. 24 - 25 (1990)

A method has been developed for obtaining mevalonolactone and 3-hydroxy-3-methylglutaric acid from an industrial waste, 4-(β-hydroxyethyl)-4-methyl-1,3-dioxane.

-

Adams,Van Duuren

, p. 2377 (1953)

-

FUNGAL METABOLITES XIII : NEW CYTOTOXIC TRITERPENE FROM HEBELOMA SPECIES (BASIDIOMYCETES)

Bernardi, M. De,Fronza, G.,Gianotti, M. P.,Mellerio, G.,Vidari, G.,Vita-Finzi, P.

, p. 1635 - 1638 (1983)

A new cytotoxic lanostane triterpene, named 3-β-acetyl-2-α-(3'-hydroxy-3'-methyl)glutarylcrustulinol, was isolated from Hebeloma crustuliniforme and H. sinapizans.The structure has been elucidated by chemical correlations and spectroscopic evidences.

POLYMERS PREPARED FROM MEVALONOLACTONE AND DERIVATIVES

-

, (2016/06/06)

Described herein polymer precursor compounds (aka polymer building blocks) of derived from biobased compounds, and specifically biobased mevalonolactone and its related derivatives. Through oxidation these biobased precursors can be reacted to yield building blocks for (unsaturated-) polyesters, polyester polyols and polyamides, as well as precursors for glycidyl esters and omega-alkenyl esters. Through reduction, these biobased precursors can be reacted to yield building blocks for (unsaturated-) polyesters, polyester polyols, polycarbonates, as well as precursors for glycidyl ethers and omega-alkenyl ethers. Through nucleophilic ring opening and/or amidation, these biobased precursors can be reacted to yield building blocks for polyester polyols, chain-extender for polyurethanes, or polyester-amides.

NATURAL MOLECULES EXTRACTED FROM BERGAMOT TISSUES, EXTRACTION PROCESS AND PHARMACEUTICAL USE

-

Page/Page column 5, (2010/04/28)

A natural molecule extracted from a citrus fruit characterized by the fact that its structure is a flavonoid linked to 3-hydroxy-3-methyl glutaric acid and an extraction process in which: the extraction of chopped fruit is conducted in pure or mixed chloroform, ethanol or methanol for a certain time, the filtrate is evaporated to dryness, the residue is submitted to solid phase extraction in order to separate the flavonoidic portion from the other class of compounds, the flavonoid mixture is separated through a preparative HPLC chromatographic system. Pharmaceutical use of the natural molecule extracted from a citrus fruit used as anticholesterol drug.

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