176848-07-0Relevant academic research and scientific papers
Synthesis of α-fluoro-β-hydroxy alkylsulfanyl esters via a nucleophilic fluorination of sulfides
Jouen,Lemaitre,Lequeux,Pommelet
, p. 10801 - 10810 (1998)
By halogen-exchange reaction using NEt3-3HF as fluoride source, methyl 2-fluoro-2-alkylsulfanyl acetate 3a-d could be obtained in good yields. Their ester enolates reacted with aromatic or aliphatic aldehydes, to lead to methyl α-atkylsulfanyl-
Synthesis of α-fluorinated-α,α-difunctionalized sulfides and sulfones
Jouen,Lasne,Pommelet
, p. 2413 - 2416 (2007/10/03)
The highly functionalized organofluorine compounds 3a-c were prepared from the activated dichlorinated sulfides 2a-c by displacement of a chlorine atom using nucleophilic fluorination agents such as dihydrogenfluoride polymer-supported. Fluorination of sulfoxides 5a-c with diethylaminosulfur trifluoride gives monofluoro sulfides 6a-c, subsequently transformed into α-chloro-α-fluoro sulfides 3a-c and sulfones 7a-c.
