176860-51-8Relevant articles and documents
Novel 1,2,4-oxadiazoles as potent and selective histamine H3 receptor antagonists
Clitherow,Beswick,Irving,Scopes,Barnes,Clapham,Brown,Evans,Hayes
, p. 833 - 838 (1996)
Replacement of the isothiourea moiety of known histamine H3 antagonists by certain 5-membered heteroaromatic systems can give compounds with an improved activity profile. One of these, 3-[(4-chlorophenyl)methyl]-5-[2-(1H-imidazol-4-yl)ethyl] 1,2,4-oxadiazole (GR175737) is a potent, selective, orally active and centally penetrating H3 antagonist.