57676-51-4

Basic information

• Product Name: (4-CHLORO-PHENYL)-ACETIC ACID HYDRAZIDE
• Synonyms: ASISCHEM D13397;ART-CHEM-BB B014952;CHEMBRDG-BB 3014952;2-(4-CHLOROPHENYL)ACETOHYDRAZIDE;(4-CHLORO-PHENYL)-ACETIC ACID HYDRAZIDE;AKOS B014952;AKOS BBB/175;2-(4-chlorophenyl)acetohydrazide(SALTDATA: FREE)
• CAS NO: 57676-51-4
• Molecular Formula: C₈H₉ClN₂O
• Molecular Weight: 184.62
• Mol File: 57676-51-4.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 394.9 °C at 760 mmHg
• Flash Point: 192.6 °C
• Appearance: /
• Density: 1.283 g/cm³
• Vapor Pressure: 1.91E-06mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (4-CHLORO-PHENYL)-ACETIC ACID HYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (4-CHLORO-PHENYL)-ACETIC ACID HYDRAZIDE(57676-51-4)
• EPA Substance Registry System: (4-CHLORO-PHENYL)-ACETIC ACID HYDRAZIDE(57676-51-4)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 57676-51-4(Hazardous Substances Data)

Usage

General Description

(4-CHLORO-PHENYL)-ACETIC ACID HYDRAZIDE is a chemical compound commonly used in the pharmaceutical industry. It is an intermediary product in the synthesis of various pharmaceuticals and agrochemicals. (4-CHLORO-PHENYL)-ACETIC ACID HYDRAZIDE has shown potential as an anti-tumor compound, and research is ongoing to explore its application in the treatment of cancer. Additionally, it is used as a key building block in the synthesis of various organic compounds and is valuable in the production of pharmaceuticals and other fine chemicals. This chemical has potential applications in medicine, agriculture, and other industries due to its versatile properties and potential therapeutic benefits.

InChI:InChI=1/C8H9ClN2O/c9-7-3-1-6(2-4-7)5-8(12)11-10/h1-4H,5,10H2,(H,11,12)

Upstream product

• 226957-05-7 tert-butyl 2-(2-(4-chlorophenyl)acetyl)hydrazinecarboxylate 
• 1878-66-6 4-chlorophenylacetic Acid 
• 140-53-4 p-chlorobenzyl cyanide 
• 14062-24-9 4-chloro-benzeneacetic acid, ethyl ester 
• 25026-34-0 4-chlorophenacetyl chloride 

Downstream Products

• 93073-38-2 2-mercapto-5-(4-chlorobenzyl)-1,3,4-oxadiazole 
• 1356585-57-3 C₁₀H₉ClN₂OS 
• 1356585-59-5 C₁₁H₁₁ClN₂OS 
• 1309582-33-9 2-ethylsulfonyl-5-(4-chlorobenzyl)-1,3,4-oxadiazole 
• 1309582-32-8 2-methylsulfonyl-5-(4-chlorobenzyl)-1,3,4-oxadiazole 
• 34547-04-1 5-(4-chloro-benzyl)-3H-[1,3,4]oxadiazol-2-one 
• 115601-14-4 4-Chlorphenylacetylazid 
• 794549-90-9 3-(4-chlorobenzyl)-6-(4-fluorophenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 

Relevant articles and documents

Expedient discovery for novel antifungal leads: 1,3,4-Oxadiazole derivatives bearing a quinazolin-4(3H)-one fragment

Developing novel fungicide candidates are intensively promoted by the rapid emergences of resistant fungi that outbreak on agricultural production. Aiming to discovery novel antifungal leads, a series of 1,3,4-oxadiazole derivatives bearing a quinazolin-4(3H)-one fragment were constructed for evaluating their inhibition effects against phytopathogenic fungi in vitro and in vivo. Systematically structural optimizations generated the bioactive molecule I32 that was identified as a promising inhibitor against Rhizoctonia solani with the in vivo preventative effect of 58.63% at 200 μg/mL. The observations that were captured by scanning electron microscopy and transmission electron microscopy demonstrated that the bioactive molecule I32 could induce the sprawling growth of hyphae, the local shrinkage and rupture on hyphal surfaces, the extreme swelling of vacuoles, the striking distortions on cell walls, and the reduction of mitochondria numbers. The above results provided an indispensable complement for the discovery of antifungal lead bearing a quinazolin-4(3H)-one and 1,3,4-oxadiazole fragment.

Carbazole-based semicarbazones and hydrazones as multifunctional anti-Alzheimer agents

With the aim to combat a multi-faceted neurodegenerative Alzheimer’s disease (AD), a series of carbazole-based semicarbazide and hydrazide derivatives were designed, synthesized and assessed for their cholinesterase (ChE) inhibitory, antioxidant and biometal chelating activity. Among them, (E)-2-((9-ethyl-9H-carbazol-3-yl)methylene)-N-(pyridin-2-yl)hydrazinecarbothioamide (62) and (E)-2-((9-ethyl-9H-carbazol-3-yl)methylene)-N-(5-chloropyridin-2-yl)hydrazinecarbothioamide (63) emerged as the premier candidates with good ChE inhibitory activities (IC50 values of 1.37 μM and 1.18 μM for hAChE, IC50 values of 2.69 μM and 3.31 μM for EqBuChE, respectively). All the test compounds displayed excellent antioxidant activity (reduction percentage of DPPH values for compounds (62) and (63) were 85.67% and 84.49%, respectively at 100 μM concentration). Compounds (62) and (63) conferred specific copper ion chelating property in metal chelation study. Molecular docking studies of compounds (62) and (63) indicate strong interactions within the active sites of both the ChE enzymes. Besides that, these compounds also exhibited significant in silico drug-like pharmacokinetic properties. Thus, taken together, they can serve as a starting point in the designing of multifunctional ligands in pursuit of potential anti-AD agents that might further prevent the progression of ADs. Communicated by Ramaswamy H. Sarma.

3,4,5-TRISUBSTITUTED-1,2,4-TRIAZOLES AND 3,4,5-TRISUBSTITUTED-3-THIO-1,2,4-TRIAZOLES AND USES THEREOF

The present disclosure describes novel compounds that are somatostatin receptor type 4 agonists.