176901-40-9Relevant academic research and scientific papers
New arylhexahydropyrimidinediones: Synthesis, benzodiazepine receptor affinity and anticonvulsant activity
Guillon,Daoust,Radulovic,Boulouard,Dallemagne,Legrand,Rault,Quermonne,Robba
, p. 335 - 339 (1996)
Synthesis of new 3-alkyl-6-arylhexahydropyrimidine-2,4-dione derivatives was achieved starting from various benzaldehydes. Their affinity towards the benzodiazepine receptor and their anticonvulsant effect were evaluated.
Synthesis and anticonvulsant activity of some new hexahydropyrimidine-2,4- dione derivatives
Septioglu, Ebubekir,Aytemir, Mutlu Dilsiz,Calis, Uensal
, p. 259 - 264 (2007/10/03)
In this study, twelve new hexahydropyrimidine-2,4-dione derivatives were synthesized and screened for their anticonvulsant activities. All the compounds (7a-l) which have 6-arylhexahydropyrimidine-2,4-dione and N,N-disubstituted dithiocarbamate structures were prepared by the reaction with appropriate 3-(2-chloroethyl)-6-arylhexahydropyrimidine-2,4-diones and the corresponding N,N-disubstituted dithiocarbamate potassium salts. The structure of the synthesized compounds was confirmed by UV, IR, 1H-NMR and elemental analysis. Their anticonvulsant activities were determined by maximal electroshock (MES), subcutaneous pentetrazol (metrazol, scMet) and rotorod toxicity tests for neurological deficits. According to the activity studies, 6-(4-chlorophenyl)hexahydropyrimidine-2,4-dione derivatives (7e-h) were found to be highly protective against MES and scMet. Neurotoxicity was not observed in any of the tested compounds.
