176908-45-5

Upstream product

• 186581-53-3 diazomethane 
• 67-56-1 methanol 
• 176908-39-7 (4S,7R,8aR)-4,7-Dibenzyl-3,6-dioxo-hexahydro-pyrrolo[1,2-a]pyrazine-2,7-dicarboxylic acid 2-tert-butyl ester 7-methyl ester 
• 141996-78-3 (4S,7R,8aR)-4,7-dibenzyl-7-methoxycarbonyl-3,6-dioxoperhydropyrrolo<1,2-a>pyrazine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 209969-08-4 (3R,5R)-3-Benzyl-5-{[(S)-2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-methyl}-1-((S)-1-methoxycarbonyl-2-phenyl-ethyl)-2-oxo-pyrrolidine-3-carboxylic acid methyl ester 
• 209969-09-5 (3R,5R)-3-Benzyl-5-{[(R)-2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-methyl}-1-((S)-1-methoxycarbonyl-2-phenyl-ethyl)-2-oxo-pyrrolidine-3-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Synthesis of highly functionalized γ-lactam derivatives for use as conformational constraints in peptides

A series of highly functionalized 2-oxopyrrolidine derivatives, as tripeptidemimetics in which the amino acid side chains are mounted on the γ-lactam template, were synthesized by nucleophilic opening of the δ-lactam system of the corresponding 3,6-dioxopyrrolo[1,2-a]pyrazine bicyclic analogues.