17696-53-6

Upstream product

• 121-33-5 vanillin 
• 62-53-3 aniline 
• 2780-47-4 C-(p-hydroxy-m-methoxyphenyl)-N-phenyl nitrone 
• 100-65-2 N-Phenylhydroxylamine 
• 98-95-3 nitrobenzene 
• 2325-27-1 N-phenyltriphenyliminophosphorane 
• 304452-49-1 Acetic acid 2-methoxy-4-[(E)-phenyliminomethyl]-phenyl ester 

Downstream Products

• 16742-60-2 vanillin semicarbazone 
• 408531-75-9 4-(chloro-anilino-methyl)-2-methoxy-phenol 
• 16435-04-4 vanilline phenylhydrazone 
• 62-53-3 aniline 
• 65729-39-7 4-[3-(4-chloro-phenyl)-4-phenyl-4,5-dihydro-[1,2,4]oxadiazol-5-yl]-2-methoxy-phenol 
• 65639-53-4 4-(1,1-dioxo-1,2,3,4-tetrahydro-1λ⁶-benzo[1,4]thiazin-3-yl)-2-methoxy-phenol 
• 65729-34-2 4-(3,4-diphenyl-4,5-dihydro-[1,2,4]oxadiazol-5-yl)-2-methoxy-phenol 
• 78993-87-0 1,2-Diphenyl-4-(4-ethoxycarbonyloxy-3-methoxybenzylidene)-Δ²-imidazolin-5-one 
• 78993-86-9 1,2-Diphenyl-4-(4-hydroxy-3-methoxybenzylidene)-Δ²-imidazolin-5-one 
• 84359-02-4 C₁₅H₁₃BrN₂O₂ 
• 76455-59-9 Methyl-carbamic acid 2-methoxy-4-[(E)-phenyliminomethyl]-phenyl ester 
• 344586-10-3 2-[(E)-2-(4-Hydroxy-3-methoxy-phenyl)-vinyl]-3-phenyl-5-[1-phenyl-meth-(Z)-ylidene]-3,5-dihydro-imidazol-4-one 
• 121-33-5 vanillin 
• 71827-79-7 2,2'-(4-hydroxy-3-methoxyphenyl)methylene bis(3-hydroxy-5,5-dimethyl-2-cyclohexene-1-one) 

Relevant academic research and scientific papers

Catalyst- And Solvent-Free Synthesis of α-Amino Polyfluoroalkylphosphonates from Bis(fluoroalkyl) Phosphonates and Aldimines

The catalyst- and solvent-free reaction between bis(fluoroalkyl) phosphonates and aldimines occurs under mild conditions (20-22 °C, 0.25-4 h) to afford a new family of α-amino polyfluoroalkylphosphonates in up to quantitative yields.

In silico, in vitro and in vivo studies indicate resveratrol analogue as a potential alternative for neuroinflammatory disorders

Inflammaging is known as an imbalance between pro-inflammatory and anti-inflammatory immune mechanisms, being related to the onset of neurological disorders, such as major depression and Alzheimer's disease. Considering the known disadvantages regarding the FDA approved drug to manage such illnesses, resveratrol emerges as a natural drug candidate, despite its low bioavailability. In this study, resveratrol analogues were evaluated for their capacity of inhibiting acetylcholinesterase in silico, in vitro, and in vivo. Molecular docking simulations pointed out RSVA1 and RSVA6 as potent inhibitors, even more than resveratrol. Ellman's assay demonstrated RSVA6 as capable of inhibiting 92.4% of the enzyme activity. Further, male Swiss mice were pretreated with RSVA6 (100 mg kg?1) 60 min before receiving scopolamine (1 mg kg?1). The Novel Recognition Object (NOR), Object Location (OLT), and Buried Pellet tests (BPL) demonstrated an RSVA6 neuroprotective effect. In the second round of tests, mice received a single intraperitoneal injection of lipopolysaccharide (0.5 mg kg?1) 24 h before treatment with RSVA6 (1, 10, and 100 mg kg?1). The Open Field (OFT), Tail Suspension (TST), and Splash tests (ST) were evaluated. LPS had no significant effect on the crossing and rearing number, indicating an association between the immobility time and anhedonia observed in the TST and ST, respectively, with depressive-like behavior. RSVA6 significantly reduced the depressive-like behavior triggered by LPS in the TST and ST. Altogether, our data suggest RSVA6 as a potential drug candidate for the treatment of neuroinflammatory conditions.

Synthesis of azomethines derived from cinnamaldehyde and vanillin: in vitro aetylcholinesterase inhibitory, antioxidant and insilico molecular docking studies

In the present study, we report the synthesis of azomethines derived from cinnamaldehyde (C1–C3) and vanillin (V1–V3) using ethanol as a green solvent in the presence of triethyl amine. The synthesized compounds were characterized and investigated for the

Comparative study on the reaction of organophosphorus reagents with moringa oleifera vanillin. Synthesis of phosphoranylidenepyranone, dioxaphospholane and butenethione derivatives as antitumor agents

VANILLIN organophosphorusfrom Moringa reagents.oleifera Treatmentplant ofwas 4-hydroxy-3-methoxybenzaldehydeallowed to react with differentnucleophilic (vanillin) with the active

Magnetic NiO nanoparticles confined within open ends MWCNTs: A novel and highly active catalyst for hydrogenation and synthesis of imines

A new nanocatalyst has been synthesized by confining magnetic nickel nanoparticles within carbon nanotubes (CNTs) and characterized by XRD, TEM, Raman and VSM. The character of the nanocatalyst passivated with a gas mixture was that it can be stored safely in air below 150 °C and needs no activation prior to use. In the catalytic test, a nickel oxide nanocatalyst confined inside the Multi-walled carbon nanotubes nanochannels (NiO/MWCNTs-in) was found to be a highly efficient and reusable catalyst for the reduction of various aromatic nitro compounds to various aromatic amines, the conversion and selectivity of which were almost up to 100% and exceed 80%. The prominent merit of the catalyst is that the overall formation rate of product inside the nanotubes exceeds that outside. Moreover, it is inexpensive, and could be prepared and scaled up easily. Besides, it can be simply separated from the reaction mixtures by an external magnetic field As a result of the possible confinement effect of CNTs, the employment of the CNTs channels as nanoreactors for catalysis may provide opportunities for the development of new heterogeneous catalysts.

Experimental and theoretical study of antioxidative properties of some salicylaldehyde and vanillic Schiff bases

The antioxidative capacity and structure-activity relationships of ten Schiff bases were investigated experimentally and theoretically. All compounds contain the aniline moiety, while the aldehyde part is either salicylaldehyde or vanillin. The DPPH assay was used to test the potential antioxidative activity of these compounds, and DFT study was used to investigate their electronic structures and provide insight into their structure-activity relationships. The effect of the position of the hydroxy, as well other groups present, on the antioxidative activity was examined. The possible radical scavenging mechanism was determined in polar (water and methanol), and nonpolar (benzene) solvents. Based on the experimental and computational results, compounds 7 and 8 exhibit the highest radical scavenging properties.

Synthesis and biological evaluation of novel N, N′-disubstituted urea and thiourea derivatives as potential anti-melanoma agents

Two series of urea and thiourea derivatives (1a11a, 1b11b) have been synthesized; all the 22 compounds were reported for the first time. Their anti-proliferative activities against the melanoma cell line B16-F10 were evaluated. Among the compounds tested,

Synthesis and voltammetric behaviour of some biologically active imines

A series of 4-{[(4-phenyl)imino}methyl}-2-methoxyphenols were synthesized and the chemical structure of these compounds were confirmed by elemental and spectral analysis. The voltammetric behaviour of all synthesized compounds was studied on DME and HMDE

Aqueous extract of the pericarp of Sapindus trifoliatus fruits: A novel 'green' catalyst for the aldimine synthesis

The catalytic efficiency in organic synthesis of the aqueous extract of the pericarp of Sapindus trifoliatus fruits was evaluated. The synthesis of a series of aldimines from aromatic aldehydes and amines was successfully catalyzed by the extract, whereas aromatic ketones and amines did not yield ketimines under comparable reaction conditions, indicating the chemoselective catalysis of the extract. The catalytic activity of the extract is due to saponins, which have a common structural skeleton containing a pentacyclic triterpenoid part substituted with different carbohydrate side chains. The mild conditions, high yields, and short reaction times not only make this protocol a valuable alternative to the conventional methods, but it also becomes significant under the roof of environmentally greener and safer processes.

Synthesis and medicinal properties of 4-benzylidene-1-phenyl-2-(substituted styryl)imidazolin-5-ones

A series of 4-benzylidene-1-phenyl-2-(substituted styryl)imidazolin-5-ones have been synthesized by the interaction of 4-benzylidene-2-methyloxazol-5-one with different Schiff bases, prepared by simple condensation of aniline and various substituted benzaldehydes. The title compounds were evaluated for antiinflammatory activity in carrageenan foot paw edema model and in vitro antioxidant activity. Among the 14 compounds synthesized, dimethyl amino derivative and sterically hindered phenolic derivatives were found to possess good antiinflammatory activity which also exhibited antioxidant properties.