58285-77-1

Upstream product

• 2780-47-4 C-(p-hydroxy-m-methoxyphenyl)-N-phenyl nitrone 
• 17696-53-6 N-(4-hydroxy-3-methoxybenzylidene)aniline 
• 121-33-5 vanillin 
• 98-95-3 nitrobenzene 
• 498-00-0 4-hydroxymethyl-2-methoxyphenol 
• 62-53-3 aniline 
• 100-65-2 N-Phenylhydroxylamine 

Downstream Products

• 1401205-07-9 C₂₁H₂₀N₂O₂S 
• 1401204-96-3 C₂₁H₂₀N₂O₃ 

Relevant academic research and scientific papers

Synthesis of an Fe-Pd bimetallic catalyst for: N -alkylation of amines with alcohols via a hydrogen auto-transfer methodology

Hydrogen auto-transfer (HAT) or borrowing hydrogen (BH) methodology which combines dehydrogenation, intermediate reaction and hydrogenation, is recognized as an excellent strategy for one-pot synthesis from an economic and environmental point of view. Although much effort has been made on the development of catalysts for HAT reactions, harsh conditions, external base or large amounts of noble metals are still required in most reported catalysis systems, and thus the exploration of a highly efficient and recyclable heterogeneous catalyst remains meaningful. In this work, a novel bimetallic catalyst, Fe10Pd1/NC500 derived from bimetallic MOF NH2-MIL-101(Fe10Pd1), has been prepared, and the catalyst exhibits superior catalytic performance for the N-alkylation of amines with alcohols via a hydrogen auto-transfer methodology. High yields of the desired products were achieved at 120 °C with an alcohol/amine molar ratio of 2?:?1 and required no external additive or solvent. A distinct enhancement in catalytic performance is observed when compared with monometallic catalysts, which can be ascribed to the "synergistic effects"inside the bimetallic alloys. The N-doped carbon support has been revealed to provide the necessary basicity which avoids the requirement of an external base. Moreover, a wide substrate range and remarkable reusability have been shown by Fe10Pd1/NC500, and this work highlights new possibilities for bimetallic catalysts applied in sustainable chemistry.

Palladium supported on magnetic nanoparticles as recoverable catalyst for one-pot reductive amination of aldehydes with nitroarenes under ambient conditions

A high-performance palladium-based catalyst has been prepared by the co-precipitation method. The catalyst was characterized by TEM, XRD, VSM and ICP. It was found that the catalyst showed a high activity for the one-pot direct reductive amination of aldehydes with nitroarenes in the presence of molecular hydrogen in ethanol, even at room temperature. Furthermore, the catalyst was easily recovered by applying an external magnet and reused for eight cycles without significant loss of activity.

Synthesis and biological evaluation of novel N, N′-disubstituted urea and thiourea derivatives as potential anti-melanoma agents

Two series of urea and thiourea derivatives (1a11a, 1b11b) have been synthesized; all the 22 compounds were reported for the first time. Their anti-proliferative activities against the melanoma cell line B16-F10 were evaluated. Among the compounds tested,

Secondary amines: Synthesis and effect of length of spacer linking two phenyl rings on biological activity

N-Benzyl benzylamines (1a-11a) and N-benzyl anilines (1b-11b) were synthesized by sodium borohydride reduction of aldimines of benzylamine and aniline respectively. The products were characterized on the basis of elemental analysis and spectral studies and screened for antifungal potential against four fungi and evaluated for nematicidal activity against two nematodes. The former compounds were found to be more effective as compared to the latter thus indicating an enhancement of biological activity due to introduction of an extra methylene group between two phenyl rings of aromatic secondary amines.

Synthesis and Reduction of Nitrones of Vanillin

Four new vanillin nitrones have been synthesized by condensing vanillin with various arylhydroxylamines.Reduction with sodium borohydride and deoxygenation with zinc dust and acetic acid were studied.