176981-17-2

Upstream product

• 176981-16-1 3-(tert-Butyl-diphenyl-silanyloxymethyl)-1,10-dimethoxy-9-[1-methoxy-meth-(E)-ylidene]-6,7,8,9-tetrahydro-benzo[g]isoquinoline 
• 931-59-9 benzenesulfenyl chloride 
• 145222-84-0 ethyl 6-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-2-methoxy-4-methyl-3-pyridinecarboxylate 
• 176981-15-0 3-(tert-Butyl-diphenyl-silanyloxymethyl)-1,10-dimethoxy-7,8-dihydro-6H-benzo[g]isoquinolin-9-one 
• 176981-13-8 3-(tert-Butyl-diphenyl-silanyloxymethyl)-1-methoxy-5a,7,8,9a-tetrahydro-5H,6H-benzo[g]isoquinoline-9,10-dione 
• 176981-14-9 3-(tert-Butyl-diphenyl-silanyloxymethyl)-10-hydroxy-1-methoxy-7,8-dihydro-6H-benzo[g]isoquinolin-9-one 

Downstream Products

• 176981-28-5 [3-(tert-Butyl-diphenyl-silanyloxymethyl)-1,10-dimethoxy-9-phenylsulfanyl-6,7,8,9-tetrahydro-benzo[g]isoquinolin-9-yl]-(1,4,5,6,8-pentamethoxy-3-phenylethynyl-naphthalen-2-yl)-methanol 
• 176981-18-3 [3-(tert-Butyl-diphenyl-silanyloxymethyl)-1,10-dimethoxy-9-phenylsulfanyl-6,7,8,9-tetrahydro-benzo[g]isoquinolin-9-yl]-(3,6-dimethoxy-2-phenylethynyl-phenyl)-methanol 
• 176981-32-1 3'-({[(1,1-dimethylethyl)diphenylsilyl]oxy}methyl)-6',7',8',9'-tetrahydro-1',4,5,6,8,9,10'-heptamethoxy-spiro[2H-benz[f]indene-2,9'-benz[g]isoquinoline]-1,3-dione 
• 176981-30-9 3'-({[(1,1-dimethylethyl)diphenylsilyl]oxy}methyl)-6',7',8',9'-tetrahydro-1',4,5,6,8,9,10'-heptamethoxy-3-(phenylmethylene)spiro[2H-benz[f]indene-2,9'-benz[g]isoquinolin]-1(3H)-one 
• 176981-29-6 3-({[(1,1-dimethylethyl)diphenylsilyl]oxy}methyl)-1,3,6',7',8',9'-hexahydro-1',4,5,6,8,9,10'-heptamethoxy-3-(phenylmethylene)spiro[2H-benz[f]indene-2,9'-benz[g]isoquinolin]-1-ol 
• 176981-31-0 C₅₆H₅₉NO₁₁Si 

Relevant academic research and scientific papers

Further model studies related to fredericamycin A: Analogues in which ring C is expanded to six atoms, and an examination of the diastereoselectivity of radical spirocyclization

The fredericamycin A analogues 5 and 23 were synthesized. A key step is the process of radical spirocyclization, and the diastereoselectivity of this reaction was studied with model compounds. In vitro tests showed that 23 was active against certain cell lines of colon and prostate cancer, while compound 5 was essentially inactive.