3-(tert-Butyl-diphenyl-silanyloxymethyl)-1,10-dimethoxy-9-phenylsulfanyl-6,7,8,9-tetrahydro-benzo[g]isoquinoline-9-carbaldehyde

Base Information

Chemical Name:3-(tert-Butyl-diphenyl-silanyloxymethyl)-1,10-dimethoxy-9-phenylsulfanyl-6,7,8,9-tetrahydro-benzo[g]isoquinoline-9-carbaldehyde
CAS No.:176981-17-2
Molecular Formula:C₃₉H₄₁NO₄SSi
Molecular Weight:647.91
Hs Code.:

Synonyms:3-(tert-Butyl-diphenyl-silanyloxymethyl)-1,10-dimethoxy-9-phenylsulfanyl-6,7,8,9-tetrahydro-benzo[g]isoquinoline-9-carbaldehyde

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Chemical Property of 3-(tert-Butyl-diphenyl-silanyloxymethyl)-1,10-dimethoxy-9-phenylsulfanyl-6,7,8,9-tetrahydro-benzo[g]isoquinoline-9-carbaldehyde

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Technology Process of 3-(tert-Butyl-diphenyl-silanyloxymethyl)-1,10-dimethoxy-9-phenylsulfanyl-6,7,8,9-tetrahydro-benzo[g]isoquinoline-9-carbaldehyde

There total 5 articles about 3-(tert-Butyl-diphenyl-silanyloxymethyl)-1,10-dimethoxy-9-phenylsulfanyl-6,7,8,9-tetrahydro-benzo[g]isoquinoline-9-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 176981-16-1
3-(tert-Butyl-diphenyl-silanyloxymethyl)-1,10-dimethoxy-9-[1-methoxy-meth-(E)-ylidene]-6,7,8,9-tetrahydro-benzo[g]isoquinoline

: 931-59-9
benzenesulfenyl chloride

: 176981-17-2
3-(tert-Butyl-diphenyl-silanyloxymethyl)-1,10-dimethoxy-9-phenylsulfanyl-6,7,8,9-tetrahydro-benzo[g]isoquinoline-9-carbaldehyde

Guidance literature:: With silver trifluoroacetate; In diethyl ether; dichloromethane; at -78 ℃; for 0.5h;
DOI:10.1016/0040-4020(96)00245-1

Reference yield:

: 145222-84-0
ethyl 6-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-2-methoxy-4-methyl-3-pyridinecarboxylate

: 176981-17-2
3-(tert-Butyl-diphenyl-silanyloxymethyl)-1,10-dimethoxy-9-phenylsulfanyl-6,7,8,9-tetrahydro-benzo[g]isoquinoline-9-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) LDA / 1.) hexane, THF, -78 deg C, 5 min, 2.) hexane, THF, -78 deg C, 3 h

2: 83 percent / DDQ / CH₂Cl₂ / 0.17 h / Ambient temperature

3: 80 percent / K₂CO₃ / acetone / 12 h / Heating

4: 1.) t-BuOK / 1.) THF, RT, 30 min, 2.) THF, RT, 1 h

5: 66 percent / CF₃COOAg / CH₂Cl₂; diethyl ether / 0.5 h / -78 °C

With potassium tert-butylate; silver trifluoroacetate; potassium carbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium diisopropyl amide; In diethyl ether; dichloromethane; acetone;
DOI:10.1016/0040-4020(96)00245-1

Reference yield:

: 176981-13-8
3-(tert-Butyl-diphenyl-silanyloxymethyl)-1-methoxy-5a,7,8,9a-tetrahydro-5H,6H-benzo[g]isoquinoline-9,10-dione

: 176981-17-2
3-(tert-Butyl-diphenyl-silanyloxymethyl)-1,10-dimethoxy-9-phenylsulfanyl-6,7,8,9-tetrahydro-benzo[g]isoquinoline-9-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / DDQ / CH₂Cl₂ / 0.17 h / Ambient temperature

2: 80 percent / K₂CO₃ / acetone / 12 h / Heating

3: 1.) t-BuOK / 1.) THF, RT, 30 min, 2.) THF, RT, 1 h

4: 66 percent / CF₃COOAg / CH₂Cl₂; diethyl ether / 0.5 h / -78 °C

With potassium tert-butylate; silver trifluoroacetate; potassium carbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In diethyl ether; dichloromethane; acetone;
DOI:10.1016/0040-4020(96)00245-1