17701-32-5

Usage

Uses

Used in Pharmaceutical Industry:
2,2-Dimethyloctanoyl chloride is used as a reagent in the synthesis of various pharmaceutical compounds. Its high reactivity allows for the formation of new chemical bonds and the creation of diverse organic molecules, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, 2,2-Dimethyloctanoyl chloride serves as a key intermediate in the production of various agrochemicals. Its ability to form new compounds makes it instrumental in the synthesis of pesticides, herbicides, and other agricultural chemicals that are essential for crop protection and yield enhancement.
Used in Polymer Industry:
2,2-Dimethyloctanoyl chloride is utilized as a monomer or a building block in the synthesis of polymers. Its reactivity enables the formation of polymer chains with specific properties, such as strength, flexibility, or chemical resistance, which are crucial in various applications, including plastics, coatings, and adhesives.
Used in Organic Synthesis:
As a versatile reagent in organic synthesis, 2,2-Dimethyloctanoyl chloride is employed in the preparation of a wide range of organic compounds. Its ability to participate in various chemical reactions, such as esterification, amide formation, and nucleophilic substitution, makes it a valuable tool for chemists in creating new molecules and advancing chemical research.

InChI:InChI=1/C10H19ClO/c1-4-5-6-7-8-10(2,3)9(11)12/h4-8H2,1-3H3

Upstream product

• 29662-90-6 dimethyloctanoic acid 
• 638-45-9 1-Iodohexane 
• 79-31-2 isobutyric Acid 

Downstream Products

• 103906-30-5 2,2-dimethyloctanamide 
• 5540-93-2 2,2-Dimethyl-octanoic acid (3-chloro-4-nitro-phenyl)-amide 
• 25228-50-6 2,2-Dimethyl-octanoic acid [3-(2,2-dimethyl-propionylamino)-phenyl]-amide 
• 25228-51-7 2,2-Dimethyl-octanoic acid [3-(2,2-dimethyl-octanoylamino)-phenyl]-amide 
• 532986-15-5 N-[(1R)-2-hydroxy-1-phenylethyl]-2,2-dimethyloctanamide 
• 97725-04-7 2,2-dimethyl-octanoic acid anilide 

Relevant academic research and scientific papers

Skin (by machine translation)

PROBLEM TO BE SOLVED: To provide a skin external preparation which has an excellent moisture retention effect, and excellent feeling of use without stickiness and strain.SOLUTION: A skin external preparation contains a copolymer that essentially consists of: one or more constitutional units derived from a hydrophobic and acrylic ester-based monomer including one (meth)acryloyl group and a plurality of acyl groups having a specific branch structure; and one or more constitutional units derived from a specific and hydrophilic structural acrylic monomer. The copolymer may have other constitutional units.

A C-H Insertion Approach to Functionalized Cyclopentenones

Cyclopentenones are synthetically versatile structures, and their straightforward construction from alkynone substrates by employing synthetically streamlining C-H insertion is conceptually appealing and of high synthetic potential. But, its implementation is very limited. Herein we report a Au-catalyzed version, which affords 2-bromocyclopent-2-en-1-ones with a broad scope and synthetically desirable diastereoselectivities. The proposed key intermediate capable of the observed insertion into unactivated C-H bonds is a fully functionalized gold vinylidene, which is generated via a novel intermolecular strategy. This flexible access of likely gold vinylidenes opens various opportunities to explore their versatile reactivities.

Intramolecular insertions into unactivated C(sp3)-H bonds by oxidatively generated β-diketone-α-gold carbenes: Synthesis of cyclopentanones

Generation of reactive α-oxo gold carbene intermediates via gold-catalyzed oxidation of alkynes has become an increasing versatile strategy of replacing hazardous diazo carbonyl compounds with benign and readily available alkynes in the development of efficient synthetic methods. However, one of the hallmarks of metal carbene/carbenoid chemistry, i.e., insertion into an unactivated C(sp3)-H bond, has not be realized. This study reveals for the first time that this highly valuable transformation can be readily realized intramolecularly by oxidatively generated β-diketone-α-gold carbenes using ynones as substrates. Substrate conformation control via the Thorpe-Ingold effect is the key design feature that enables generally good to excellent efficiencies, and synthetically versatile cyclopentanones including spiro-, bridged, and fused bicyclic ones can be readily accessed.

Highly potent inhibitors of TNF-α production. Part I: Discovery of new chemical leads and their structure-activity relationships

Discovery of new chemical leads of inhibitors for TNF-α production starting from the chemical modification of 1 is reported. Further biological studies of 1 to disclose the site of its action strongly suggested that 1 inhibits LPS-induced TNF-α expression