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Usage

Uses

Used in Pharmaceutical Industry:
Trilostane is used as a medication for the treatment of Cushing's syndrome, a hormonal disorder characterized by an excess of cortisol in the body. It functions by inhibiting the enzyme 3-beta-hydroxysteroid dehydrogenase, which is crucial in the biosynthesis of cortisol. By doing so, trilostane helps to reduce the production of cortisol in the adrenal glands, effectively managing the symptoms of Cushing's syndrome such as weight gain, high blood pressure, and diabetes. This makes trilostane an important therapeutic agent in the management of this condition.

Upstream product

• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 1452-23-9 (5α)-pregnane-3,20-dione 20-(1,2-ethanediyl acetal) 
• 566-65-4 dihydroprogesterone 
• 18003-79-7 3,3-dimethoxy-5α-pregnan-20-one 

Relevant academic research and scientific papers

C17, C20, AND C21 SUBSTITUTED NEUROACTIVE STEROIDS AND THEIR METHODS OF USE

Described herein are neuroactive steroids or a pharmaceutically acceptable salt thereof. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. Also provided are pharmaceutical compositions comprising a compound described herein and methods of use and treatment, e.g., such as for inducing sedation and/or anesthesia.

ANDROSTANE AND PREGNANE SERIES FOR ALLOSTERIC MODULATION OF GABA RECEPTOR

Methods, compositions, and compounds for modulating the GABAA receptor-chloride ionophore complex to alleviate stress, anxiety, seizures, mood disorders, PMS and PND and to induce anesthesia.

Synthesis and in vitro activity of 3β-substituted-3α-hydroxypregnan- 20-ones: Allosteric modulators of the GABA(A) receptor

Two naturally occurring metabolites of progesterone, 3α-hydroxy-5α- and 5β-pregnan-20-one (1 and 2), are potent allosteric modulators of the GABA(A) receptor. Their therapeutic potential as anxiolytics, anticonvulsants, and sedative/hypnotics is limited b