177093-56-0

Basic information

• Product Name: Benzoic acid, 4-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl]-, methyl ester
• CAS NO: 177093-56-0
• Molecular Formula: C21H21NO4
• Molecular Weight: 351.402
• Mol File: 177093-56-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl]-, methyl ester(177093-56-0)
• EPA Substance Registry System: Benzoic acid, 4-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl]-, methyl ester(177093-56-0)

Safety Data

• Hazardous Substances Data: 177093-56-0(Hazardous Substances Data)

Upstream product

• 52787-14-1 methyl 4-(2-methoxy-2-oxoethyl)benzoate 
• 17754-90-4 4-(Diethylamino)salicylaldehyde 

Downstream Products

• 177093-58-2 3-(4-bromomethylphenyl)-7-diethylamino-2H-1-benzopyran-2-one 
• 177093-57-1 7-Diethylamino-3-(4-hydroxymethyl-phenyl)-chromen-2-one 
• 150460-77-8 4-(7-Diethylamino-2-oxo-2H-chromen-3-yl)-benzoic acid 

Relevant articles and documents

3-[4-(Bromomethyl)phenyl]-7-(diethylamino)-2H-1-benzopyran-2-one (MPAC-Br): A highly sensitive fluorescent derivatization reagent for carboxylic acids in high-performance liquid chromatography

7-Dimethylaminocoumarin derivatives were synthesized and the characteristics of their absorption and emission spectra were investigated. Among them, 3-aryl-7-dimethylaminocoumarins were shown to be promising candidates as the fluorogenic groups for highly sensitive derivatization reagents. Based on the spectroscopic studies, 3-[4-(bromomethyl)phenyl]-7-(diethylamino)-2H-1-benzopyran-2-one (MPAC-Br) was designed and synthesized as a fluorescent derivatization reagent for carboxylic acids in HPLC. Saturated carboxylic acids (C4-C18) were derivatized almost quantitatively into the corresponding fluorescent MPAC-esters by treatment with MPAC-Br. The MPAC-esters of these acids were clearly separated on a reversed-phase HPLC column (Inertsil ODS-2, mobile phase: methanol-water, excitation wavelength 403 nm; emission wavelength 474 nm). The detection limit (S/N=17) of lauric acid, as a test compound, was 15fmol/10μl.