17716-80-2

Upstream product

• 1798-11-4 4-nitrophenoxyacetic acid 
• 62-53-3 aniline 
• 20142-88-5 2-(4-nitrophenoxy)acetyl chloride 
• 100-02-7 4-nitro-phenol 
• 587-65-5 N-chloroacetyl-aniline 
• 33901-46-1 2-(4-nitrophenoxy)acetonitrile 
• 66003-76-7 Diphenyliodonium triflate 
• 5625-99-0 N,N'-diphenylphosphorodiamidic chloride 

Downstream Products

• 64485-32-1 2-(4-aminophenoxy)-N-phenylacetamide 
• 836-30-6 4-ntrophenyl(phenyl)amine 
• 936632-66-5 1-deoxy-1-(6-{4-[(phenylcarbamoyl)methoxy]phenylamino}-9H-purin-9-yl)-N-ethyl-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide 
• 936632-82-5 1-deoxy-1-(2-chloro-6-{4-[(phenylcarbamoyl)methoxy]phenylamino}-9H-purin-9-yl)-N-ethyl-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide 
• 118989-62-1 N-(4-nitrophenyl)-N-phenyl-2-chloroacetamide 

Relevant academic research and scientific papers

Copper-catalyzed transformation of alkyl nitriles to N -arylacetamide using diaryliodonium salts

This work reports a simple and efficient method for the copper-catalyzed redox-neutral transformation of alkyl nitriles using eco-friendly diaryliodonium salts and leading to N-arylacetamides. The method features high efficiency, broad substrate scope and good functional group tolerance.

N6-[(Hetero)aryl/(cyclo)alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5′-N-ethylcarboxamido-adenosines: The first example of adenosine-related structures with potent agonist activity at the human A2B adenosine receptor

A new series of N6-[(hetero)aryl/(cyclo)alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5′-N-ethylcarboxamido-adenosines (24-43) has been synthesised and tested in binding assays at hA1, hA2A and hA3 adenosine receptors, and in a functional assay at the hA2B subtype. The examined compounds displayed high potency in activating A2B receptors with good selectivity versus A2A subtypes. The introduction of an unsubstituted 4-[(phenylcarbamoyl)-methoxy]-phenyl chain at the N6 position of 5′-N-ethylcarboxamido-adenosine led us to the recognition of compound 24 as a full agonist displaying the highest efficacy of the series (EC50 hA2B = 7.3 nM). These compounds represent the first report about adenosine-related structures capable of activating hA2B subtype in the low nanomolar range.

A convenient preparation of N-alkyl and N-arylamines by smiles rearrangement - Synthesis of analogues of diclofenac

Smiles rearrangement of substituted aryloxyacetamides in which oxygen and nitrogen are separated by COCH2 group has been successful even when the aryloxy ring carries weak or no electron withdrawing group. Earlier reports of such reactions involved either strong electron withdrawing groups or a special catalyst. The diphenylamines thus obtained gave analogues of diclofenac in only one case.

N,N'-Diphenylphosphorodiamido Chloridate, a Novel Reagent for the Synthesis of Anilides

N,N'-Diphenylphosphorodiamido chloridate (I) is found to be a suitable reagent for the synthesis of anilides (II) of carboxylic acids.A plausible reaction mechanism has been proposed.