177164-76-0Relevant academic research and scientific papers
AMINOGUANIDINE HYDRAZONES AS RETROMER STABILIZERS USEFUL FOR TREATING NEUROLOGICAL DISEASES
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Page/Page column 22; 55, (2020/10/20)
The present invention relates to novel aminoguanidine hydrazone-derivatives of Formula (I) which are effective as retromer stabilizers and useful as neuroprotecting drugs. The invention also relates to pharmaceutical compositions comprising the compounds and their use in therapy and diagnostic.
The role of magnetic nanoparticles (MNP) as reducing agents in an MNP-supported Pd-catalyst for the reductive homocoupling of aryl halides
Zheng, Jie,Lin, Shengyue,Jiang, Bi-Wang,Marder, Todd B.,Yang, Zhen
, p. 138 - 144 (2012/03/07)
A palladium pincer catalyst grafted onto the surface of magnetic nanoparticles (MNPs) has been developed. This material effectively catalyzes the reductive homocoupling of various aryl halide substrates, with the MNP support acting as the reducing agent. The catalyst can be recycled up to five times in the absence of additional reducing agent to give almost quantitative yields of biaryl homocoupling products. After the reducing power of the MNP has been depleted, the supported Pd complex remains an effective catalyst for Suzuki-Miyaura cross-coupling.
Preparation of tethered palladium catalysis supported on gold(111) and its surface characterization by X-ray photoelectron spectroscopy (XPS)
Gulam, Rabbani M.,Hamada, Masahiro,Takamiya, Ikuko,Shimoda, Masahiko,Shuto, Satoshi,Nishida, Atsushi,Tsukamoto, Shiro,Arisawa, Mitsuhiro
scheme or table, p. 1012 - 1018 (2009/04/13)
Chelated tethering ligands were confined on a Au(111) substrate, and the confinement of the ligands was confirmed by X-ray photoelectron spectroscopy (XPS). Palladium was anchored to the ligands to construct heterogeneous (Pd)-L-Au(111) catalysts (L = lig
Evidence that SCS pincer Pd(II) complexes are only precatalysts in Heck catalysis and the implications for catalyst recovery and reuse
Yu, Kunquan,Sommer, William,Richardson, John M.,Weck, Marcus,Jones, Christopher W.
, p. 161 - 171 (2007/10/03)
SCS-pincer Pd(II) complexes have been covalently immobilized onto porous silica, cross-linked polymer (Merrifield resin) and soluble poly(norbornene) supports via either amide or urea linkages and evaluated in the Heck coupling of iodobenzene with n-butyl acrylate. Kinetic experiments and poisoning studies indicate that in all cases the pincer complexes merely act as precatalysts. Contrary to literature reports, there is no evidence for catalysis by the intact amide-linked SCS-Pd(II) complexes under any conditions studied here.
Tridentate SCS palladium(II) complexes: New, highly stable, recyclable catalysts for the Heck reaction
Bergbreiter, David E.,Osburn, Philip L.,Liu, Yun-Shan
, p. 9531 - 9538 (2007/10/03)
A new pincer-type SCS ligand containing Pd(II) is a simple, robust catalyst for Heck chemistry using a variety of alkene acceptors and aryl iodides. It is less active with aryl bromides. While certain palladium-(II) species insert slowly into the aryl C-H bond of an unsubstituted version of this ligand, the introduction of activating groups into the 5 position of the aromatic ring readily allows quantitative metal insertion. These ligands were synthesized and attached to soluble polymers by simple modification of inexpensive starting materials. For example, both 5-oxy and 5-amido SCS ligands were successfully appended to 5000 Mn poly-(ethylene glycol) via ether or amide linkages, respectively. Both the 5-oxo and 5-amido complexes are active as Heck catalysts in DMF solution in air. The PEG-bound 5-amido-SCS-Pd complex was recycled via solvent precipitation three times with no observed catalyst deactivation. While the 5-amido-SCS-Pd complexes are very robust, their 5-oxo counterparts decompose slowly under certain conditions. These SCS catalysts are analogous to PCP-type catalysts previously reported in the literature but avoid the requirement of an air-sensitive phosphine synthesis.
