867259-24-3

Upstream product

• 71176-54-0 (3-amino-5-hydroxymethylphenyl)methanol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 71176-55-1 5-nitro-m-xylene-(α,α')-diol 

Downstream Products

• 867259-28-7 1-[3,5-bis(4,4'-dimethoxytrityloxymethyl)phenyl]uracil 
• 867259-29-8 1-[3,5-bis(4,4'-dimethoxytrityloxymethyl)phenyl]cytosine 
• 867259-31-2 4-N-benzoyl-1-[3-(tert-butyldimethylsilanyloxymethyl)-5-(4,4'-dimethoxytrityloxymethyl)phenyl]cytosine 
• 867259-32-3 4-N-benzoyl-1-[3-(4,4'-dimethoxytrityloxymethyl)-5-(hydroxymethyl)phenyl]cytosine 
• 867259-27-6 1-[3-(tert-butyldimethylsilanyloxymethyl)-5-(4,4'-dimethoxytrityloxymethyl)phenyl]uracil 
• 867259-30-1 1-[3-(tert-butyldimethylsilanyloxymethyl)-5-(4,4'-dimethoxytrityloxymethyl)phenyl]cytosine 
• 867259-26-5 1-[3-(4,4'-dimethoxytrityloxymethyl)-5-(hydroxymethyl)phenyl]uracil 

Relevant academic research and scientific papers

AMINOGUANIDINE HYDRAZONES AS RETROMER STABILIZERS USEFUL FOR TREATING NEUROLOGICAL DISEASES

The present invention relates to novel aminoguanidine hydrazone-derivatives of Formula (I) which are effective as retromer stabilizers and useful as neuroprotecting drugs. The invention also relates to pharmaceutical compositions comprising the compounds and their use in therapy and diagnostic.

CYTOTOXIC BENZODIAZEPINE DERIVATIVES

The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VI). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.

Synthesis and properties of nucleic acid analogues consisting of a benzene-phosphate backbone

The synthesis and properties of a nucleic acid analogue consisting of a benzene-phosphate backbone are described. The building blocks of the nucleic acid analogue are composed of bis(hydroxymethyl)-benzene residues connected to nucleobases via the biaryl-like axis. Stabilities of the duplexes were studied by thermal denaturation. It was found that the thermal stabilities of the duplexes composed of the benzene-phosphate backbone are highly dependent on their sequences. The duplexes with the benzene-phosphate backbone comprised of the mixed sequences were thermally less stable than the natural DNA duplexes, whereas that composed of the homopyrimidine and homopurine sequences was thermally and thermodynamically more stable than the corresponding natural DNA duplex. It was suggested that the analogues more efficiently stabilize the duplexes in a B-form duplex rather than in an A-form duplex. Thus, the duplexes consisting of the benzene-phosphate backbone, especially composed of the homopyrimidine and homopurine sequences, may offer a novel structural motif useful for developing novel materials applicable in the fields of bio- and nanotechnologies.